Nanomechanical characterization of pressurized elastic fluid nanovesicles using indentation analysis
文献类型：期刊论文
| 作者 | Tang, Xingyi1; Shi, Xinghua2; Gan, Yong3,4 ; Yi, Xin1,5
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| 刊名 | EXTREME MECHANICS LETTERS
 |
| 出版日期 | 2020 |
| 卷号 | 34页码:9 |
| ISSN号 | 2352-4316 |
| 关键词 | Indentation Nanovesicles Osmotic pressure Young's modulus Stiffness |
| DOI | 10.1016/j.eml.2019.100613 |
| 通讯作者 | Yi, Xin(xyi@pku.edu.cn) |
| 英文摘要 | Mechanical properties play fundamental roles in regulating the biological behaviors of nanovesicles in a wide range of implications including cell uptake, intercellular communication and developing nanocarriers for drug delivery. Here we theoretically probe the mechanical properties of nanovesicles using indentation analysis based on a minimal model fully accounting for both small and large indentation without introducing unphysical contact and geometrical conditions. Two types of vesicles are considered: one having a fixed area and the other undergoing areal stretch. The indentation response of pressurized elastic fluid vesicles depends on the membrane bending rigidity, osmotic pressure, adhesion energy and size of the indenter tip. Moreover, the osmotic pressure dominates the indentation response, effective stiffness and Young's modulus for strongly pressurized vesicles. An analytical and universal relation which offers a new and easy way to determine the osmotic pressure from the measured indentation force-depth curve is identified. Effects of the nanovesicle size on the effective stiffness at finite and zero osmotic pressures are analyzed and show significantly different trends. Further discussion is made on the differences between the indentation of fluid vesicles and solid thin shells. (C) 2019 Elsevier Ltd. All rights reserved. |
| WOS关键词 | LIPID-BILAYERS ; MEMBRANES ; EXOSOMES ; ADHESION ; VESICLE ; AFM ; TRANSLOCATION ; NANOPARTICLES ; DEFORMATION ; MECHANICS |
| 资助项目 | National Natural Science Foundation of China[11872005] |
| WOS研究方向 | Engineering ; Materials Science ; Mechanics |
| 语种 | 英语 |
| 出版者 | ELSEVIER |
| WOS记录号 | WOS:000510479300010 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/281602]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Yi, Xin |
| 作者单位 | 1.Peking Univ, Coll Engn, Dept Mech & Engn Sci, Beijing 100871, Peoples R China 2.Chinese Acad Sci, CAS Ctr Excellence Nanosci, Natl Ctr Nanosci & Technol, CAS Key Lab Nanosyst & Hierarchy Fabricat, Beijing 100190, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 5.Peking Univ, Beijing Innovat Ctr Engn Sci & Adv Technol, Beijing 100871, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tang, Xingyi,Shi, Xinghua,Gan, Yong,et al. Nanomechanical characterization of pressurized elastic fluid nanovesicles using indentation analysis[J]. EXTREME MECHANICS LETTERS,2020,34:9. |
| APA | Tang, Xingyi,Shi, Xinghua,Gan, Yong,&Yi, Xin.(2020).Nanomechanical characterization of pressurized elastic fluid nanovesicles using indentation analysis.EXTREME MECHANICS LETTERS,34,9. |
| MLA | Tang, Xingyi,et al."Nanomechanical characterization of pressurized elastic fluid nanovesicles using indentation analysis".EXTREME MECHANICS LETTERS 34(2020):9. |
入库方式： OAI收割
来源：上海药物研究所
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