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Rapid transport of germ-mimetic nanoparticles with dual conformational polyethylene glycol chains in biological tissues

文献类型：期刊论文

作者Yang, Yiwei1,3; Tian, Falin2; Nie, Di1,3; Liu, Yuan1; Qian, Kun1,3; Yu, Miaorong1,3; Wang, Aohua1,3; Zhang, Yaqi1,3; Shi, Xinghua2,3; Gan, Yong1,3
刊名SCIENCE ADVANCES
出版日期2020-02-01
卷号6期号:6页码:16
ISSN号2375-2548
DOI10.1126/sciadv.aay9937
通讯作者Shi, Xinghua(shixh@nanoctr.cn) ; Gan, Yong(ygan@simm.ac.cn)
英文摘要Polyethylene glycols (PEGs) can improve the diffusivity of nanoparticles (NPs) in biological hydrogels, while extended PEG chains severely impede cellular uptake of NPs. Inspired by invasive germs with flagellum-driven mucus-penetrating and fimbriae-mediated epithelium-adhering abilities, we developed germ-mimetic NPs (GMNPs) to overcome multiple barriers in mucosal and tumor tissues. In vitro studies and computational simulations revealed that the tip-specific extended PEG chains on GMNP functioned similarly to flagella, facilitating GMNP diffusion (up to 83.0-fold faster than their counterparts). Meanwhile, the packed PEG chains on the bodies of GMNP mediated strong adhesive interactions with cells similarly to the fimbriae, preserving cellular uptake efficiency. The in vivo results proved the superior tumor permeability and improved oral bioavailability provided by the GMNP (21.9-fold over administration of crystalline drugs). These findings offer useful guidelines for the rational design of NPs by manipulating surface polymer conformation to realize multiple functions and to enhance delivery efficacy.
WOS关键词CELL-ADHESION ; SURFACE ; DENSITY ; PEG ; HYDROPHILICITY ; ADSORPTION ; PARTICLES ; DELIVERY ; SIZE ; KEY
资助项目National Natural Science Foundation of China[81773651] ; National Natural Science Foundation of China[11422215] ; National Natural Science Foundation of China[11272327] ; National Natural Science Foundation of China[11672079] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDA12050307] ; K.C. Wong Education Foundation ; Opening Fund of the State Key Laboratory of Nonlinear Mechanics, Chinese Academy of Sciences ; China Postdoctoral Science Foundation[2019M650602]
WOS研究方向Science & Technology - Other Topics
语种英语
出版者AMER ASSOC ADVANCEMENT SCIENCE
WOS记录号WOS:000512902300037
源URL[http://119.78.100.183/handle/2S10ELR8/281610]  
专题中国科学院上海药物研究所
通讯作者Shi, Xinghua; Gan, Yong
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, 501 Haike Rd, Shanghai 201203, Peoples R China
2.Chinese Acad Sci, Natl Ctr Nanosci & Technol, Key Lab Nanosyst & Hierarchy Fabricat, CAS Ctr Excellence Nanosci,Lab Theoret & Computat, Beijing 100190, Peoples R China
3.Univ Chinese Acad Sci, 19AYuquan Rd, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Yang, Yiwei,Tian, Falin,Nie, Di,et al. Rapid transport of germ-mimetic nanoparticles with dual conformational polyethylene glycol chains in biological tissues[J]. SCIENCE ADVANCES,2020,6(6):16.
APA Yang, Yiwei.,Tian, Falin.,Nie, Di.,Liu, Yuan.,Qian, Kun.,...&Gan, Yong.(2020).Rapid transport of germ-mimetic nanoparticles with dual conformational polyethylene glycol chains in biological tissues.SCIENCE ADVANCES,6(6),16.
MLA Yang, Yiwei,et al."Rapid transport of germ-mimetic nanoparticles with dual conformational polyethylene glycol chains in biological tissues".SCIENCE ADVANCES 6.6(2020):16.

入库方式： OAI收割

来源：上海药物研究所

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