Stimuli-activatable nanomedicines for chemodynamic therapy of cancer
文献类型：期刊论文
| 作者 | Wang, Weiqi1,4,5; Jin, Yilan1,4,5; Xu, Zhiai3; Liu, Xiao4; Bajwa, Sadia Z.2; Khan, Waheed S.2; Yu, Haijun1,5
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| 刊名 | WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
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| 出版日期 | 2020-02-03 |
| 页码 | 14 |
| 关键词 | cancer nanomedicine chemodynamic therapy Fenton reaction stimuli responsive tumor microenvironment |
| ISSN号 | 1939-5116 |
| DOI | 10.1002/wnan.1614 |
| 通讯作者 | Yu, Haijun(hjyu@simm.ac.cn) |
| 英文摘要 | Chemodynamic therapy (CDT) takes the advantages of Fenton-type reactions triggered by endogenous chemical energy to generate highly cytotoxic hydroxyl radicals. As a novel modality for cancer treatment, CDT shows minimal invasiveness and high tumor specificity by responding to the acidic and the highly concentrated hydrogen peroxide microenvironment of tumor. The CDT approach for spatiotemporal controllable reactive oxygen species generation exhibits preferable therapeutic performance and satisfying biosafety. In this review article, we summarized the recent advances of stimuli-activatable nanomedicines for CDT. We also overviewed the strategies for augmenting CDT performance, including increasing the catalytic efficacy through rational design of the nanomaterials, modulating the reaction condition, inputting external energy field, and regulating the tumor microenvironment. Furthermore, we discussed the potential and challenges of stimuli-activatable nanomedicine for clinical translation and future development of CDT. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease Nanotechnology Approaches to Biology > Nanoscale Systems in Biology Diagnostic Tools > In Vivo Nanodiagnostics and Imaging |
| WOS关键词 | IRON-OXIDE NANOPARTICLES ; FENTON REACTION ; MICROENVIRONMENT ; STRESS |
| 资助项目 | Natural Science Foundation of Nantong in China[JC2018153] ; National Natural Science Foundation of China[31900990] ; National Natural Science Foundation of China[31671024] ; National Natural Science Foundation of China[51873228] |
| WOS研究方向 | Science & Technology - Other Topics ; Research & Experimental Medicine |
| 语种 | 英语 |
| WOS记录号 | WOS:000510500900001 |
| 出版者 | WILEY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/281627]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Yu, Haijun |
| 作者单位 | 1.Chinese Acad Sci, Ctr Pharmaceut, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 2.NIBGE, Nanobiotechnol Grp, Faisalabad, Pakistan 3.East China Normal Univ, Sch Chem & Mol Engn, Shanghai, Peoples R China 4.Nantong Univ, Sch Pharm, Nantong, Peoples R China 5.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Weiqi,Jin, Yilan,Xu, Zhiai,et al. Stimuli-activatable nanomedicines for chemodynamic therapy of cancer[J]. WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY,2020:14. |
| APA | Wang, Weiqi.,Jin, Yilan.,Xu, Zhiai.,Liu, Xiao.,Bajwa, Sadia Z..,...&Yu, Haijun.(2020).Stimuli-activatable nanomedicines for chemodynamic therapy of cancer.WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY,14. |
| MLA | Wang, Weiqi,et al."Stimuli-activatable nanomedicines for chemodynamic therapy of cancer".WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY (2020):14. |
入库方式： OAI收割
来源：上海药物研究所
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