Self-assembling mertansine prodrug improves tolerability and efficacy of chemotherapy against metastatic triple-negative breast cancer
文献类型：期刊论文
| 作者 | Ran, Wei2,3,6; Liu, Xiaoyu2,3,7; Chang, Lu1; Cai, Ying2,3,6; Zheng, Chao2,3,8; Liu, Jia1,6 ; Li, Yaping2,3,4,5,6; Zhang, Pengcheng2,3,4,6
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| 刊名 | JOURNAL OF CONTROLLED RELEASE
 |
| 出版日期 | 2020-02-01 |
| 卷号 | 318页码:234-245 |
| 关键词 | Supramolecular Self-assembly Prodrug Chemotherapy Triple-negative breast cancer |
| ISSN号 | 0168-3659 |
| DOI | 10.1016/j.jconrel.2019.12.027 |
| 通讯作者 | Li, Yaping(ypli@simm.ac.cn) ; Zhang, Pengcheng(pzhang@simm.ac.cn) |
| 英文摘要 | Metastatic triple-negative breast cancer is one of the most devastating cancer types. Systemic chemotherapy is necessary, but its clinical performance is largely limited by severe side effects. Herein, we report a mertansine prodrug, which could self-assemble into spherical nanoparticles in water and readily convert into active mertansine at the presence of glutathione. The self-assembling mertansine prodrugs (SAMPDs) entered cancer cells via a caveolae-mediated pathway and exhibited potent cytotoxicity. The self-delivering SAMPDs did not cause hemolysis, and more importantly increased maximum tolerated dose (MTD) of mertansine by 8 folds via reducing free mertansine exposure in most of the major organs. SAMPDs improved intratumoral drug exposure and showed dose-dependent antitumor activity. When dosed at MTD, SAMPDs inhibited primary tumor growth and pulmonary metastasis by 80% and 95%, while mertansine dosed at MTD only reduced primary tumor growth and metastasis by < 50% and 60%, respectively. Our results reveal the mechanism of in vivo biotransformation of self-assembling prodrug and highlight the unique advantages of self-assembling prodrug strategy in improving the efficacy and safety of chemotherapy. |
| WOS关键词 | CELLULAR INTERNALIZATION ; CYTOTOXIC DRUG ; DELIVERY ; PACLITAXEL ; CAMPTOTHECIN ; PLATFORM ; NANOCARRIERS ; CONJUGATE ; CARRIER ; POLYMERIZATION |
| 资助项目 | National Natural Science Foundation of China[81671808] ; National Natural Science Foundation of China[31870995] ; National Natural Science Foundation of China[81630052] ; National Natural Science Foundation of China[81690265] ; Youth Innovation Promotion Association of CAS[2017335] ; SA-SIBS Scholarship Program |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000512735400021 |
| 出版者 | ELSEVIER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/281640]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Li, Yaping; Zhang, Pengcheng |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Metab & Pharmacokinet Res, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 501 Haike Rd, Shanghai 201203, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, 501 Haike Rd, Shanghai 201203, Peoples R China 4.Yantai Inst Mat Med, Yantai Key Lab Nanomed & Adv Preparat, Yantai 264000, Shandong, Peoples R China 5.Yantai Univ, Sch Pharm, Yantai 264005, Shandong, Peoples R China 6.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 7.Univ Sci & Technol China, Nano Sci & Technol Inst, Suzhou 215123, Peoples R China 8.China State Inst Pharmaceut Ind, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ran, Wei,Liu, Xiaoyu,Chang, Lu,et al. Self-assembling mertansine prodrug improves tolerability and efficacy of chemotherapy against metastatic triple-negative breast cancer[J]. JOURNAL OF CONTROLLED RELEASE,2020,318:234-245. |
| APA | Ran, Wei.,Liu, Xiaoyu.,Chang, Lu.,Cai, Ying.,Zheng, Chao.,...&Zhang, Pengcheng.(2020).Self-assembling mertansine prodrug improves tolerability and efficacy of chemotherapy against metastatic triple-negative breast cancer.JOURNAL OF CONTROLLED RELEASE,318,234-245. |
| MLA | Ran, Wei,et al."Self-assembling mertansine prodrug improves tolerability and efficacy of chemotherapy against metastatic triple-negative breast cancer".JOURNAL OF CONTROLLED RELEASE 318(2020):234-245. |
入库方式： OAI收割
来源：上海药物研究所
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