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Identifying a ten-microRNA signature as a superior prognosis biomarker in colon adenocarcinoma

文献类型：期刊论文

作者Ma, Rong2,3; Zhao, Yanyun2,3; He, Miao2,3; Zhao, Hongliang2,3; Zhang, Yifan2,3; Zhou, Shuqi2,3; Gao, Mengcong2,3; Di, Di2,3; Wang, Jue2,3; Ding, Jian1,2
刊名CANCER CELL INTERNATIONAL
出版日期2019-12-30
卷号19期号:1页码:16
关键词Colon adenocarcinoma MicroRNAs Biomarker Prognosis
DOI10.1186/s12935-019-1074-9
通讯作者Ding, Jian(jding@simm.ac.cn) ; Wei, Minjie(weiminjiecmu@163.com)
英文摘要Background Increasing studies have suggested that aberrant expression of microRNAs might play essential roles in the progression of cancers. In this study, we sought to construct a high-specific and superior microRNAs signature to improve the survival prediction of colon adenocarcinoma (COAD) patients. Methods The genome-wide miRNAs, mRNA and lncRNA expression profiles and corresponding clinical information of COAD were collected from the TCGA database. Differential expression analysis, Kaplan-Meier curve and time-dependent ROC curve were calculated and performed using R software and GraphPad Prism7. Univariate and multivariate Cox analysis was performed to evaluate the prognostic ability of signature. Functional enrichment analysis was analyzed using STRING database. Results We identified ten prognosis-related microRNAs, including seven risky factors (hsa-miR-197, hsa-miR-32, hsa-miR-887, hsa-miR-3199-2, hsa-miR-4999, hsa-miR-561, hsa-miR-210) and three protective factors (hsa-miR-3917, hsa-miR-3189, hsa-miR-6854). The Kaplan-Meier survival analysis showed that the patients with high risk score had shorter overall survival (OS) in test series. And the similar results were observed in both validation and entire series. The time-dependent ROC curve suggested this signature have high accuracy of OS for COAD. The Multivariate Cox regression analysis and stratification analysis suggested that the ten-microRNA signature was an independent factor after being adjusted with other clinical characteristics. In addition, we also found microRNA signature have higher AUC than other signature. Furthermore, we identified some miRNA-target genes that affect lymphatic metastasis and invasion of COAD patients. Conclusion In this study, we established a ten-microRNA signature as a potentially reliable and independent biomarker for survival prediction of COAD patients.
WOS关键词NONCODING RNA SIGNATURE ; COLORECTAL-CANCER ; METASTASIS ; MICRORNAS ; HETEROGENEITY ; CARCINOMA ; SURVIVAL ; INVASION
资助项目National Natural Science Foundation of China and Liaoning joint fund key program[U1608281] ; Double Hundred Program for Shenyang Scientific and Technological Innovation Projects[Z18-4-020] ; Double Hundred Program for Shenyang Scientific and Technological Innovation Projects[100040]
WOS研究方向Oncology
语种英语
出版者BMC
WOS记录号WOS:000513526700003
源URL[http://119.78.100.183/handle/2S10ELR8/281751]  
专题新药研究国家重点实验室
通讯作者Ding, Jian; Wei, Minjie
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, Div Antitumor Pharmacol, State Key Lab Drug Res, Shanghai, Peoples R China
2.China Med Univ, Sch Pharm, Dept Pharmacol, 77 Puhe Rd, Shenyang 110122, Liaoning, Peoples R China
3.China Med Univ, Liaoning Engn Technol Res Ctr, 77 Puhe Rd, Shenyang 110122, Liaoning, Peoples R China
推荐引用方式
GB/T 7714		 Ma, Rong,Zhao, Yanyun,He, Miao,et al. Identifying a ten-microRNA signature as a superior prognosis biomarker in colon adenocarcinoma[J]. CANCER CELL INTERNATIONAL,2019,19(1):16.
APA Ma, Rong.,Zhao, Yanyun.,He, Miao.,Zhao, Hongliang.,Zhang, Yifan.,...&Wei, Minjie.(2019).Identifying a ten-microRNA signature as a superior prognosis biomarker in colon adenocarcinoma.CANCER CELL INTERNATIONAL,19(1),16.
MLA Ma, Rong,et al."Identifying a ten-microRNA signature as a superior prognosis biomarker in colon adenocarcinoma".CANCER CELL INTERNATIONAL 19.1(2019):16.

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来源：上海药物研究所

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