Fluorescence imaging of a potential diagnostic biomarker for breast cancer cells using a peptide-functionalized fluorogenic 2D material
文献类型：期刊论文
| 作者 | Dou, Wei-Tao3; Liu, Li-Fang3,4; Gao, Jie3,4; Zang, Yi4 ; Chen, Guo-Rong3; Field, Robert A.1; James, Tony D.2; Li, Jia4; He, Xiao-Peng3
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| 刊名 | CHEMICAL COMMUNICATIONS
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| 出版日期 | 2019-11-14 |
| 卷号 | 55期号:88页码:13235-13238 |
| ISSN号 | 1359-7345 |
| DOI | 10.1039/c9cc06399d |
| 通讯作者 | Zang, Yi(yzang@simm.ac.cn) ; Li, Jia(jli@simm.ac.cn) ; He, Xiao-Peng(xphe@ecust.edu.cn) |
| 英文摘要 | Protein C receptor (PROCR) is a recently discovered transmembrane biomarker for several tissue stem cells and is highly expressed in triple-negative breast cancer (TNBC) patient-derived xenografts. Herein, to enrich the toolbox for the biochemical evaluation of PROCR, we have developed a peptide-functionalized fluorogenic 2D material based on the self-assembly between a fluorescent peptide probe and thin-layer molybdenum disulfide. The material developed was suitable for the sensitive detection of PROCR recombinant protein in buffer solution and the fluorescence imaging of TNBC cells that express high levels of PROCR. |
| WOS关键词 | PROTEIN-C RECEPTOR ; ACTIVATION |
| 资助项目 | Natural Science Foundation of China[21788102] ; Natural Science Foundation of China[91853201] ; Natural Science Foundation of China[21722801] ; Natural Science Foundation of China[21776078] ; Shanghai Municipal Science and Technology Major Project[2018SHZDZX03] ; Shanghai Science and Technology Committee[19410712600] ; National Postdoctoral Program for Innovative Talents[BX20190115] ; Royal Society |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| 出版者 | ROYAL SOC CHEMISTRY |
| WOS记录号 | WOS:000495086800004 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/281766]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Zang, Yi; Li, Jia; He, Xiao-Peng |
| 作者单位 | 1.John Innes Ctr, Dept Biol Chem, Norwich Res Pk, Norwich NR4 7UH, Norfolk, England 2.Univ Bath, Dept Chem, Bath BA2 7AY, Avon, England 3.East China Univ Sci & Technol, Sch Chem & Mol Engn, Feringa Nobel Prize Scientist Joint Res Ctr, Key Lab Adv Mat, 130 Meilong Rd, Shanghai 200237, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, Natl Ctr Drug Screening, State Key Lab Drug Res, 189 Guo Shoujing Rd, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Dou, Wei-Tao,Liu, Li-Fang,Gao, Jie,et al. Fluorescence imaging of a potential diagnostic biomarker for breast cancer cells using a peptide-functionalized fluorogenic 2D material[J]. CHEMICAL COMMUNICATIONS,2019,55(88):13235-13238. |
| APA | Dou, Wei-Tao.,Liu, Li-Fang.,Gao, Jie.,Zang, Yi.,Chen, Guo-Rong.,...&He, Xiao-Peng.(2019).Fluorescence imaging of a potential diagnostic biomarker for breast cancer cells using a peptide-functionalized fluorogenic 2D material.CHEMICAL COMMUNICATIONS,55(88),13235-13238. |
| MLA | Dou, Wei-Tao,et al."Fluorescence imaging of a potential diagnostic biomarker for breast cancer cells using a peptide-functionalized fluorogenic 2D material".CHEMICAL COMMUNICATIONS 55.88(2019):13235-13238. |
入库方式： OAI收割
来源：上海药物研究所
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