Organo-Catalyzed Asymmetric Amination of 4-Arylisoquinoline-1,3(2H,4H)-dione Derivatives in the Construction of Quaternary Stereocenters
文献类型：期刊论文
| 作者 | Cheng, Cheng2; Li, Ying-Xian2; Zhang, Ji-Quan2; Zhao, Yong-Long2; Zhang, Lin2; Li, Chun2; Yang, Yu-she1 ; Tang, Lei2; Yang, Yuan-Yong2
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| 刊名 | ADVANCED SYNTHESIS & CATALYSIS
 |
| 出版日期 | 2019-10-22 |
| 页码 | 6 |
| 关键词 | Isoquinoline-1,3(2H,4H)-dione Amination reaction Asymmetric catalysis Bifunctional catalyst |
| ISSN号 | 1615-4150 |
| DOI | 10.1002/adsc.201900980 |
| 通讯作者 | Tang, Lei(tlei1974@hotmail.com) ; Yang, Yuan-Yong(yangyuanyong@gmc.edu.cn) |
| 英文摘要 | An efficient method has been developed for the enantioselective amination of 4-arylisoquinoline-1,3(2H,4H)-dione derivatives. In the presence of squaramide-based catalyst, the alpha-amination cyclic imides were delivered in excellent yields (up to 99%) and ee (up to 99%) under mild conditions. Moreover, a gram scale synthetic application was also demonstrated. |
| WOS关键词 | ENANTIOSELECTIVE ALPHA-AMINATIONS ; ELECTROPHILIC AMINATION ; KETONES ; DESIGN |
| 资助项目 | National Natural Science Foundation of China[81660348] ; State Key Laboratory of Drug Research[SIMM1903KF-09] ; Office of Science & Technology of Guizhou[[2018]5779-62] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000494093500001 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/281771]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Tang, Lei; Yang, Yuan-Yong |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Guizhou Med Univ, Sch Pharm, Guizhou Prov Engn Technol Res Ctr Chem Drug R&D, State Key Lab Funct & Applicat Med Plants, Guiyang 550014, Guizhou, Peoples R China |
| 推荐引用方式 GB/T 7714 | Cheng, Cheng,Li, Ying-Xian,Zhang, Ji-Quan,et al. Organo-Catalyzed Asymmetric Amination of 4-Arylisoquinoline-1,3(2H,4H)-dione Derivatives in the Construction of Quaternary Stereocenters[J]. ADVANCED SYNTHESIS & CATALYSIS,2019:6. |
| APA | Cheng, Cheng.,Li, Ying-Xian.,Zhang, Ji-Quan.,Zhao, Yong-Long.,Zhang, Lin.,...&Yang, Yuan-Yong.(2019).Organo-Catalyzed Asymmetric Amination of 4-Arylisoquinoline-1,3(2H,4H)-dione Derivatives in the Construction of Quaternary Stereocenters.ADVANCED SYNTHESIS & CATALYSIS,6. |
| MLA | Cheng, Cheng,et al."Organo-Catalyzed Asymmetric Amination of 4-Arylisoquinoline-1,3(2H,4H)-dione Derivatives in the Construction of Quaternary Stereocenters".ADVANCED SYNTHESIS & CATALYSIS (2019):6. |
入库方式： OAI收割
来源：上海药物研究所
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