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Amphiphilic drug-drug conjugate for cancer therapy with combination of chemotherapeutic and antiangiogenesis drugs

文献类型：期刊论文

作者Sun, Mo2; Qian, Qiuhui2; Shi, Leilei2; Xu, Li2; Liu, Qunfang1; Zhou, Linzhu2; Zhu, Xinyuan2; Yue, Jian-Min1; Yan, Deyue2
刊名SCIENCE CHINA-CHEMISTRY
出版日期2019-10-21
页码7
ISSN号1674-7291
关键词nanoparticle combination therapy cancer treatment supramolecular chemistry
DOI10.1007/s11426-019-9602-4
通讯作者Zhu, Xinyuan(xyzhu@sjtu.edu.cn) ; Yue, Jian-Min(jmyue@mail.shcnc.ac.cn) ; Yan, Deyue(dyyan@sjtu.edu.cn)
英文摘要The progression and metastasis of solid tumors strongly rely on the process of forming nascent blood vessels. However, using angiogenesis inhibitors alone does not meet the cancer treatment needs. Herein, we used the amphiphilic drug-drug conjugate (ADDC) strategy to fabricate a new drug conjugate with the combination of chemotherapeutic drug and antiangiogenesis drug together. With one-step esterification of hydrophilic floxuridine (FUDR) and hydrophobic pseudolaric acid B (PAB), the conjugate was synthesized. The amphiphilic property of FUDR-PAB conjugate induced the self-assembly to form nanoparticles in water. From further in vitro and in vivo experiments, this FUDR-PAB conjugate does not only have a high antitumor effect, but also shows efficient antianiogenesis property. These results offer a promising ADDC strategy for designing drugs with combination of chemotherapeutic drug and antiangiogenesis drug together.
WOS关键词TARGETED DELIVERY ; NANOPARTICLES ; FLOXURIDINE ; NANODRUG ; NANOMEDICINE ; DOXORUBICIN ; RESISTANCE ; PRODRUG ; TUMORS
资助项目National Basic Research Program[2015CB931801] ; National Natural Science Foundation of China[51690151] ; National Natural Science Foundation of China[21504055]
WOS研究方向Chemistry
语种英语
出版者SCIENCE PRESS
WOS记录号WOS:000492171000003
源URL[http://119.78.100.183/handle/2S10ELR8/281777]  
专题新药研究国家重点实验室
通讯作者Zhu, Xinyuan; Yue, Jian-Min; Yan, Deyue
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
2.Shanghai Jiao Tong Univ, Sch Chem & Chem Engn, State Key Lab Met Matrix Composites, Shanghai 200240, Peoples R China
推荐引用方式
GB/T 7714		 Sun, Mo,Qian, Qiuhui,Shi, Leilei,et al. Amphiphilic drug-drug conjugate for cancer therapy with combination of chemotherapeutic and antiangiogenesis drugs[J]. SCIENCE CHINA-CHEMISTRY,2019:7.
APA Sun, Mo.,Qian, Qiuhui.,Shi, Leilei.,Xu, Li.,Liu, Qunfang.,...&Yan, Deyue.(2019).Amphiphilic drug-drug conjugate for cancer therapy with combination of chemotherapeutic and antiangiogenesis drugs.SCIENCE CHINA-CHEMISTRY,7.
MLA Sun, Mo,et al."Amphiphilic drug-drug conjugate for cancer therapy with combination of chemotherapeutic and antiangiogenesis drugs".SCIENCE CHINA-CHEMISTRY (2019):7.

入库方式： OAI收割

来源：上海药物研究所

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