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Monomeric and dimeric sesquiterpene lactones from Artemisia heptapotamica

文献类型：期刊论文

作者Abilova, Zhamilya1,4,5; Yuan Jie1,4,5; Jenis, Janar3,4,5; Tang Chun-Ping4,5; Ye Yang2,4,5
刊名CHINESE JOURNAL OF NATURAL MEDICINES
出版日期2019-10-01
卷号17期号:10页码:785-791
关键词Artemisia heptapotamica Artemisiane E Artemdubolide I Ajaniaolide B Sesquiterpene lactone Anti-inflammation
ISSN号2095-6975
通讯作者Ye Yang(yye@shcnc.ac.cn)
英文摘要One new dimeric (1) and two monomeric sesquiterpene lactones (5 and 13), together with 10 known compounds (2-4, 6-12), were isolated from Artemisia heptapotamica collected in Almaty region of Kazakhstan. All compounds were isolated from this plant for the first time. The structures of the new compounds were mainly achieved by extensive analysis of MS, 1D and 2D NMR spectroscopic data, and ECD spectrum as well. The inhibitory activities of all isolates against activation of NF-kappa B induced by LPS were assessed on a THP1-Dual cell model. Some of them showed strong inhibitory activity with IC50 values ranging from 2 to 25 mu mol.L-1.
资助项目International Partnership Program of Chinese Academy of Sciences[153631KYSB20160004] ; National Natural Science Foundation of China[81573305] ; National Natural Science Foundation of China[81673327] ; Ministry of Education and Science of the Republic of Kazakhstan[0118PK00458]
WOS研究方向Integrative & Complementary Medicine ; Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000495018100008
出版者CHINESE JOURNAL NATURAL MEDICINES
源URL[http://119.78.100.183/handle/2S10ELR8/281828]  
专题新药研究国家重点实验室
通讯作者Ye Yang
作者单位1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
2.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China
3.Al Farabi Kazakh Natl Univ, Res Ctr Med Plants, Al Farabi Ave 71, Alma Ata 050040, Kazakhstan
4.Chinese Acad Sci, Shanghai Inst Mat Med, Nat Prod Chem Dept, Shanghai 201203, Peoples R China
5.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Abilova, Zhamilya,Yuan Jie,Jenis, Janar,et al. Monomeric and dimeric sesquiterpene lactones from Artemisia heptapotamica[J]. CHINESE JOURNAL OF NATURAL MEDICINES,2019,17(10):785-791.
APA Abilova, Zhamilya,Yuan Jie,Jenis, Janar,Tang Chun-Ping,&Ye Yang.(2019).Monomeric and dimeric sesquiterpene lactones from Artemisia heptapotamica.CHINESE JOURNAL OF NATURAL MEDICINES,17(10),785-791.
MLA Abilova, Zhamilya,et al."Monomeric and dimeric sesquiterpene lactones from Artemisia heptapotamica".CHINESE JOURNAL OF NATURAL MEDICINES 17.10(2019):785-791.

入库方式： OAI收割

来源：上海药物研究所

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