Protein dynamics and conformational changes explored by hydrogen/deuterium exchange mass spectrometry
文献类型：期刊论文
| 作者 | Zheng, Jie1,2,3; Strutzenberg, Timothy2,3; Pascal, Bruce D.2,3,4; Griffin, Patrick R.2,3 |
| 刊名 | CURRENT OPINION IN STRUCTURAL BIOLOGY
 |
| 出版日期 | 2019-10-01 |
| 卷号 | 58页码:305-313 |
| ISSN号 | 0959-440X |
| DOI | 10.1016/j.sbi.2019.06.007 |
| 通讯作者 | Griffin, Patrick R.(pgriffin@scripps.edu) |
| 英文摘要 | Proteins are not rigid bodies under their physiological conditions. Here we discuss a solution-phase structural proteomics technique, hydrogen deuterium exchange coupled with mass spectrometry (HDX-MS), as a means to study protein dynamics, which can complement other structural approaches. We outline the background theory and highlight the utility of HDX-MS measurements in two case studies involving a nuclear receptor and an innate immunity receptor. We also discuss emerging software advances for improving data analysis and three-dimensional visualization. |
| WOS关键词 | HYDROGEN-DEUTERIUM EXCHANGE ; SINGLETON-MERTEN SYNDROME ; TIME WINDOW ; CROSS-LINKING ; RIG-I ; MS ; TECHNOLOGY ; EXPANSION ; PEPTIDES ; DOMAIN |
| WOS研究方向 | Biochemistry & Molecular Biology ; Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000494891800037 |
| 出版者 | CURRENT BIOLOGY LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/281831]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Griffin, Patrick R. |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 2.Scripps Res Inst, Dept Mol Med, Jupiter, FL 33458 USA 3.Scripps Res Inst, Dept Integrat Struct & Computat Biol, Jupiter, FL 33458 USA 4.Omics Informat LLC, Honolulu, HI 96813 USA |
| 推荐引用方式 GB/T 7714 | Zheng, Jie,Strutzenberg, Timothy,Pascal, Bruce D.,et al. Protein dynamics and conformational changes explored by hydrogen/deuterium exchange mass spectrometry[J]. CURRENT OPINION IN STRUCTURAL BIOLOGY,2019,58:305-313. |
| APA | Zheng, Jie,Strutzenberg, Timothy,Pascal, Bruce D.,&Griffin, Patrick R..(2019).Protein dynamics and conformational changes explored by hydrogen/deuterium exchange mass spectrometry.CURRENT OPINION IN STRUCTURAL BIOLOGY,58,305-313. |
| MLA | Zheng, Jie,et al."Protein dynamics and conformational changes explored by hydrogen/deuterium exchange mass spectrometry".CURRENT OPINION IN STRUCTURAL BIOLOGY 58(2019):305-313. |
入库方式： OAI收割
来源：上海药物研究所
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