Peptide Nanotube-Templated Biomineralization of Cu2-xS Nanoparticles for Combination Treatment of Metastatic Tumor
文献类型：期刊论文
| 作者 | Lai, Yi2; Xu, Zhiai2; Hu, Xianli2; Lei, Li2; Li, Lingling2; Dong, Liang2; Yu, Haijun1,3 ; Zhang, Wen2
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| 刊名 | SMALL
 |
| 出版日期 | 2019-10-22 |
| 页码 | 13 |
| 关键词 | biomineralization cancer metastasis combination therapy Fenton reaction peptide nanotubes |
| ISSN号 | 1613-6810 |
| DOI | 10.1002/smll.201904397 |
| 通讯作者 | Xu, Zhiai(zaxu@chem.ecnu.edu.cn) ; Zhang, Wen(wzhang@chem.ecnu.edu.cn) |
| 英文摘要 | 1D peptide nanostructures (i.e., peptide nanotubes, PNTs) exhibit tunable chemo-physical properties and functions such as improved tissue adhesion, increased cellular uptake, and elongated blood circulation. In this study, the application of PNTs as a desirable 1D template for biomineralization of Cu2-xS nanoparticles (Cu2-xS NPs, x = 1-2) is reported. Monodisperse Cu2-xS NPs are uniformly coated on the peptide nanotubes owing to the specific high binding affinity of Cu ions to the imidazole groups exposed on the surface of nanotubes. The Cu2-xS NP-coated PNTs are further covalently grafted with an oxaliplatin prodrug (Pt-CuS-PNTs) to construct a versatile nanoplatform for combination cancer therapy. Upon 808 nm laser illumination, the nanoplatform induces significant hyperthermia effect and elicits reactive oxygen species generation through electron transfer and Fenton-like reaction. It is demonstrated that the versatile nanoplatform dramatically inhibits tumor growth and lung metastasis of melanoma in a B16-F10 melanoma tumor-bearing mouse model by combined photo- and chemotherapy. This study highlights the ability of PNTs for biomineralization of metal ions and the promising potential of such nanoplatforms for cancer treatment. |
| WOS关键词 | PHOTODYNAMIC THERAPY ; PHOTOTHERMAL THERAPY ; BIOMIMETIC SYNTHESIS ; BREAST-CANCER ; MINERALIZATION ; NANOCRYSTALS ; OXYGEN ; DELIVERY ; CELLS ; NANOCOMPOSITES |
| 资助项目 | National Natural Science Foundation of China[21775046] ; National Natural Science Foundation of China[21675055] ; National Natural Science Foundation of China[21635003] ; Fundamental Research Funds for the Central Universities |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:000494117200001 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/281858]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Xu, Zhiai; Zhang, Wen |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.East China Normal Univ, Sch Chem & Mol Engn, Shanghai 200241, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lai, Yi,Xu, Zhiai,Hu, Xianli,et al. Peptide Nanotube-Templated Biomineralization of Cu2-xS Nanoparticles for Combination Treatment of Metastatic Tumor[J]. SMALL,2019:13. |
| APA | Lai, Yi.,Xu, Zhiai.,Hu, Xianli.,Lei, Li.,Li, Lingling.,...&Zhang, Wen.(2019).Peptide Nanotube-Templated Biomineralization of Cu2-xS Nanoparticles for Combination Treatment of Metastatic Tumor.SMALL,13. |
| MLA | Lai, Yi,et al."Peptide Nanotube-Templated Biomineralization of Cu2-xS Nanoparticles for Combination Treatment of Metastatic Tumor".SMALL (2019):13. |
入库方式： OAI收割
来源：上海药物研究所
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