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Ruthenium(II)-Catalyzed C-H Acylmethylation between (Hetero)arenes and alpha-Cl Ketones/Sulfoxonium Ylides

文献类型：期刊论文

作者Li, Huihui1,2,3; Wu, Chenglin2,3; Liu, Hong2,3; Wang, Jiang2,3
刊名JOURNAL OF ORGANIC CHEMISTRY
出版日期2019-11-01
卷号84期号:21页码:13262-13275
ISSN号0022-3263
DOI10.1021/acs.joc.9b01013
通讯作者Liu, Hong(hliu@simm.ac.cn) ; Wang, Jiang(jwang@simm.ac.cn)
英文摘要The first ruthenium(II)-catalyzed (hetero)arene C-H activation coupling with alpha-Cl ketones/sulfoxonium ylides to efficiently generate acylmethylated (hetero)arenes has been described. Compared with the previous studies, this transformation constitutes the first coupling of alpha-Cl ketones with arenes under low-cost Ru(II) complex catalysis. Meanwhile, sulfoxonium ylides functioning as the surrogates of alpha-Cl ketones were also used to facilitate acylmethylation of (hetero)arenes. This strategy features high efficiency, wide substrate tolerance, easily accessible starting materials, and mild reaction conditions.
WOS关键词ONE-POT SYNTHESIS ; SULFOXONIUM YLIDES ; BOND ACTIVATION ; CATALYZED HYDROARYLATIONS ; DIRECT HYDROXYMETHYLATION ; PROPARGYL ALCOHOLS ; N-TOSYLHYDRAZONES ; ALLYLIC ALCOHOLS ; DIAZO-COMPOUNDS ; RUTHENIUM
资助项目National Natural Science Foundation of China[21672232] ; National Natural Science Foundation of China[21632008] ; National Natural Science Foundation of China[21877118] ; National Natural Science Foundation of China[81620108027] ; National S&T Major Projects[2015ZX09103003] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDA12040201]
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000494562600006
出版者AMER CHEMICAL SOC
源URL[http://119.78.100.183/handle/2S10ELR8/281904]  
专题新药研究国家重点实验室
通讯作者Liu, Hong; Wang, Jiang
作者单位1.Univ Sci & Technol China, Nano Sci & Technol Inst, 166 Ren Ai Rd, Suzhou 215123, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Li, Huihui,Wu, Chenglin,Liu, Hong,et al. Ruthenium(II)-Catalyzed C-H Acylmethylation between (Hetero)arenes and alpha-Cl Ketones/Sulfoxonium Ylides[J]. JOURNAL OF ORGANIC CHEMISTRY,2019,84(21):13262-13275.
APA Li, Huihui,Wu, Chenglin,Liu, Hong,&Wang, Jiang.(2019).Ruthenium(II)-Catalyzed C-H Acylmethylation between (Hetero)arenes and alpha-Cl Ketones/Sulfoxonium Ylides.JOURNAL OF ORGANIC CHEMISTRY,84(21),13262-13275.
MLA Li, Huihui,et al."Ruthenium(II)-Catalyzed C-H Acylmethylation between (Hetero)arenes and alpha-Cl Ketones/Sulfoxonium Ylides".JOURNAL OF ORGANIC CHEMISTRY 84.21(2019):13262-13275.

入库方式： OAI收割

来源：上海药物研究所

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