Tetramerized Sesquiterpenoid Ainsliatetramers A and B from Ainsliaea fragrans and Their Cytotoxic Activities
文献类型：期刊论文
| 作者 | Zhang, Rui1,5,6; Tang, Chunping1,6 ; Liu, Hong-Chun2; Ren, Yongmei1,4,5,6; Ke, Chang-Qiang1,6; Yao, Sheng1,6; Cai, Yaoyao3; Zhang, Naixia3; Ye, Yang1,4,6
|
| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2019-10-18 |
| 卷号 | 21期号:20页码:8211-8214 |
| ISSN号 | 1523-7060 |
| DOI | 10.1021/acs.orglett.9b02909 |
| 通讯作者 | Ye, Yang(yye@simm.ac.cn) |
| 英文摘要 | Two guaianolide sesquiterpenoid tetramers named ainsliatetramers A and B were separated from Ainsliaea fragrans. Through spectroscopic analyses, especially the band-selective CT-HSQC and CT-HMBC techniques, the complex skeleton was constructed from four sesquiterpene units via three different linkages. A biosynthetic pathway was proposed featuring a Michael addition and a regular and a hetero-Diels-Alder cycloaddition. Both exhibited potent cytotoxicity against human cancer cell lines with IC50 values ranging from 2 to 15 mu M. |
| WOS关键词 | ALKALOIDS ; SKELETON ; TRIMERS ; DIMER |
| 资助项目 | National Science & Technology Major Project Key New Drug Creation and Manufacturing Program[2015ZX09103002] ; National Natural Science Foundation of China[81573305] ; National Natural Science Foundation of China[81673327] ; International Partnership Program of Chinese Academy of Sciences[153631KYSB20160004] ; International Partnership Program of Chinese Academy of Sciences[153631KYSB20170043] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000492114600015 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/281909]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Ye, Yang |
| 作者单位 | 1.Chinese Acad Sci, Nat Prod Chem Dept, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Div Antitumor Pharmacol, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 3.Chinese Acad Sci, Dept Analyt Chem, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 4.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China 5.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 6.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Rui,Tang, Chunping,Liu, Hong-Chun,et al. Tetramerized Sesquiterpenoid Ainsliatetramers A and B from Ainsliaea fragrans and Their Cytotoxic Activities[J]. ORGANIC LETTERS,2019,21(20):8211-8214. |
| APA | Zhang, Rui.,Tang, Chunping.,Liu, Hong-Chun.,Ren, Yongmei.,Ke, Chang-Qiang.,...&Ye, Yang.(2019).Tetramerized Sesquiterpenoid Ainsliatetramers A and B from Ainsliaea fragrans and Their Cytotoxic Activities.ORGANIC LETTERS,21(20),8211-8214. |
| MLA | Zhang, Rui,et al."Tetramerized Sesquiterpenoid Ainsliatetramers A and B from Ainsliaea fragrans and Their Cytotoxic Activities".ORGANIC LETTERS 21.20(2019):8211-8214. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。