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Palladium-Catalyzed Ring-Opening Coupling of gem-Difluorocyclopropanes for the Construction of 2-Fluoroallylic Sulfones

文献类型：期刊论文

作者Ni, Jiabin1,3; Nishonov, Bekzod1,3; Pardaev, Azizbek1,3; Zhang, Ao1,2,3
刊名JOURNAL OF ORGANIC CHEMISTRY
出版日期2019-11-01
卷号84期号:21页码:13646-13654
ISSN号0022-3263
DOI10.1021/acs.joc.9b01897
通讯作者Zhang, Ao(aozhang@simm.ac.cn)
英文摘要A Pd-catalyzed ring-opening sulfonylation of gem-difluorocyclopropanes is reported. This protocol involves C-C bond cleavage, beta-F elimination, and allylic coupling to form corresponding 2-fluoroallylic sulfones efficiently with Z-selectivity. Different substrates bearing diverse functional groups are tolerated. Moreover, this method is successfully used for the late-stage derivation of several bioactive molecules.
WOS关键词BIOLOGICAL EVALUATION ; DIFLUORINATED CYCLOPROPANES ; DESIGN ; FLUORINE ; POTENT ; AGENTS ; FLUOROOLEFINS ; DERIVATIVES ; INHIBITORS ; ANALOGS
资助项目National Program on Key Basic Research Project of China[2015CB910603-004] ; Chinese National NSF[81430080] ; Chinese National NSF[81773565]
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000494562600039
出版者AMER CHEMICAL SOC
源URL[http://119.78.100.183/handle/2S10ELR8/281927]  
专题中国科学院上海药物研究所
通讯作者Zhang, Ao
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China
2.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Ni, Jiabin,Nishonov, Bekzod,Pardaev, Azizbek,et al. Palladium-Catalyzed Ring-Opening Coupling of gem-Difluorocyclopropanes for the Construction of 2-Fluoroallylic Sulfones[J]. JOURNAL OF ORGANIC CHEMISTRY,2019,84(21):13646-13654.
APA Ni, Jiabin,Nishonov, Bekzod,Pardaev, Azizbek,&Zhang, Ao.(2019).Palladium-Catalyzed Ring-Opening Coupling of gem-Difluorocyclopropanes for the Construction of 2-Fluoroallylic Sulfones.JOURNAL OF ORGANIC CHEMISTRY,84(21),13646-13654.
MLA Ni, Jiabin,et al."Palladium-Catalyzed Ring-Opening Coupling of gem-Difluorocyclopropanes for the Construction of 2-Fluoroallylic Sulfones".JOURNAL OF ORGANIC CHEMISTRY 84.21(2019):13646-13654.

入库方式： OAI收割

来源：上海药物研究所

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