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Enhancing Triple Negative Breast Cancer Immunotherapy by ICG-Templated Self-Assembly of Paclitaxel Nanoparticles

文献类型：期刊论文

作者Feng, Bing1,2,3; Niu, Zifei1,3; Hou, Bo1,3; Zhou, Lei1,3; Li, Yaping1,2,3; Yu, Haijun1,2,3
刊名ADVANCED FUNCTIONAL MATERIALS
出版日期2019-11-08
页码13
ISSN号1616-301X
关键词immune checkpoint blockade immunogenic cell death immunotherapy self-assemble triple negative breast cancer
DOI10.1002/adfm.201906605
通讯作者Li, Yaping(ypli@simm.ac.cn) ; Yu, Haijun(hjyu@simm.ac.cn)
英文摘要Combination cancer immunotherapy has shown promising potential for simultaneously eliciting antitumor immunity and modulating the immunosuppressive tumor microenvironment (ITM). However, combination immunotherapy with multiple regimens suffers from the varied chemo-physical properties and inconsistent pharmacokinetic profiles of the different therapeutics. To achieve tumor-specific codelivery of the immune modulators, an indocyanine green (ICG)-templated self-assembly strategy for preparing dual drug-loaded two-in-one nanomedicine is reported. ICG-templated self-assembly of paclitaxel (PTX) nanoparticles (ISPN), and the application of ISPN for combination immunotherapy of the triple negative breast cancer (TNBC) are demonstrated. The ISPN show satisfied colloidal stability and high efficacy for tumor-specific codelivery of ICG and PTX through the enhanced tumor permeability and retention effect. Upon laser irradiation, the ICG component of ISPN highly efficiently induces immunogenic cell death of the tumor cells via activating antitumor immune response through photodynamic therapy. Meanwhile, PTX delivered by ISPN suppresses the regulatory T lymphocytes (T-regs) to combat ITM. The combination treatment of TNBC with ISPN and alpha PD-L1-medaited immune checkpoint blockade therapy displays a synergistic effect on tumor regression, metastasis inhibition, and recurrence prevention. Overall, the ICG-templated nanomedicine may represent a robust nanoplatform for combination immunotherapy.
WOS关键词CARRIER-FREE ; PHOTODYNAMIC THERAPY ; PD-L1 EXPRESSION ; CELL ; CHEMOTHERAPY ; BLOCKADE ; DELIVERY
资助项目National Natural Science Foundation of China[31671024] ; National Natural Science Foundation of China[51873228] ; National Natural Science Foundation of China[31622025] ; National Natural Science Foundation of China[81521005] ; Strategic Priority Research Program of CAS[XDA12050307] ; Youth Innovation Promotion Association of Chinese Academy of Sciences[2014218]
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种英语
出版者WILEY-V C H VERLAG GMBH
WOS记录号WOS:000495140000001
源URL[http://119.78.100.183/handle/2S10ELR8/281930]  
专题新药研究国家重点实验室
通讯作者Li, Yaping; Yu, Haijun
作者单位1.Chinese Acad Sci, Ctr Pharmaceut, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Feng, Bing,Niu, Zifei,Hou, Bo,et al. Enhancing Triple Negative Breast Cancer Immunotherapy by ICG-Templated Self-Assembly of Paclitaxel Nanoparticles[J]. ADVANCED FUNCTIONAL MATERIALS,2019:13.
APA Feng, Bing,Niu, Zifei,Hou, Bo,Zhou, Lei,Li, Yaping,&Yu, Haijun.(2019).Enhancing Triple Negative Breast Cancer Immunotherapy by ICG-Templated Self-Assembly of Paclitaxel Nanoparticles.ADVANCED FUNCTIONAL MATERIALS,13.
MLA Feng, Bing,et al."Enhancing Triple Negative Breast Cancer Immunotherapy by ICG-Templated Self-Assembly of Paclitaxel Nanoparticles".ADVANCED FUNCTIONAL MATERIALS (2019):13.

入库方式： OAI收割

来源：上海药物研究所

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