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A New Sesquiterpenoid from Chrysanthemum indicum

文献类型：期刊论文

作者Chen, Jia2,3; Yang, Xu4; Li, Bo1,5; Yang, Kun4; Wang, Yiqin3; Sun, Kexing2; Zhang, Yong1,5; Zhu, Weiliang1,5
刊名CHEMISTRY OF NATURAL COMPOUNDS
出版日期2019-11-11
页码4
关键词Chrysanthemum indicum sesquiterpenoid glucoside nitric oxide production
ISSN号0009-3130
DOI10.1007/s10600-019-02898-y
通讯作者Wang, Yiqin() ; Zhang, Yong(zhangyong109@simm.ac.cn)
英文摘要A novel glucoside sesquiterpenoid (1) was isolated from Chrysanthemum indicum L. flowers, together with 14 known compounds (2-15), among which eight compounds (3, 4, 8, and 10-14) were isolated from the plant for the first time. Their structures were determined on the basis of the interpretation of spectroscopic data, viz., ESI-MS, HR-TOF-MS, IR, and NMR. The effects of these compounds onlipopolysaccharide-induced nitric oxide production by RAW 264.7 cells were investigated. Compounds 2, 3, and 7 showed strong or moderate inhibitory effects at 100 mu M, and the IC50 values of 3 and 7 were 36.09 and 9.59 mu M, respectively.
WOS关键词CHEMICAL-CONSTITUENTS ; FLOWERS ; GLYCOSIDES
资助项目Natural Science Foundation of Young Scholars of China[81603270] ; China Postdoctoral Science Foundation[2017M611608] ; Shanghai Sailing Program[16YF1414100]
WOS研究方向Pharmacology & Pharmacy ; Chemistry
语种英语
WOS记录号WOS:000495704200022
出版者SPRINGER
源URL[http://119.78.100.183/handle/2S10ELR8/281935]  
专题中国科学院上海药物研究所
通讯作者Wang, Yiqin; Zhang, Yong
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, Drug Discovery & Design Ctr, Shanghai 201203, Peoples R China
2.Shanghai Jiao Tong Univ, Shanghai Childrens Med Ctr, Shanghai 200127, Peoples R China
3.Shanghai Univ Tradit Chinese Med, Shanghai 201203, Peoples R China
4.Chengdu Univ Tradit Chinese Med, Chengdu 611137, Sichuan, Peoples R China
5.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Chen, Jia,Yang, Xu,Li, Bo,et al. A New Sesquiterpenoid from Chrysanthemum indicum[J]. CHEMISTRY OF NATURAL COMPOUNDS,2019:4.
APA Chen, Jia.,Yang, Xu.,Li, Bo.,Yang, Kun.,Wang, Yiqin.,...&Zhu, Weiliang.(2019).A New Sesquiterpenoid from Chrysanthemum indicum.CHEMISTRY OF NATURAL COMPOUNDS,4.
MLA Chen, Jia,et al."A New Sesquiterpenoid from Chrysanthemum indicum".CHEMISTRY OF NATURAL COMPOUNDS (2019):4.

入库方式： OAI收割

来源：上海药物研究所

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