TRAIL-based gene delivery and therapeutic strategies
文献类型：期刊论文
| 作者 | Zhong, Hui-hai1,2; Wang, Hui-yuan1 ; Li, Jian2; Huang, Yong-zhuo1
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| 刊名 | ACTA PHARMACOLOGICA SINICA
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| 出版日期 | 2019-11-01 |
| 卷号 | 40期号:11页码:1373-1385 |
| 关键词 | TRAIL gene delivery gene therapy DNA drug delivery systems non-viral vectors cancer therapy |
| ISSN号 | 1671-4083 |
| DOI | 10.1038/s41401-019-0287-8 |
| 通讯作者 | Huang, Yong-zhuo(yzhuang@simm.ac.cn) |
| 英文摘要 | TRAIL (tumor necrosis factor-related apoptosis-inducing ligand), also known as APO2L, belongs to the tumor necrosis factor family. By binding to the death receptor 4 (DR4) or DR5, TRAIL induces apoptosis of tumor cells without causing side toxicity in normal tissues. In recent years TRAIL-based therapy has attracted great attention for its promise of serving as a cancer drug candidate. However, the treatment efficacy of TRAIL protein was under expectation in the clinical trials because of the short half-life and the resistance of cancer cells. TRAIL gene transfection can produce a "bystander effect" of tumor cell killing and provide a potential solution to TRAIL-based cancer therapy. In this review we focus on TRAIL gene therapy and various design strategies of TRAIL DNA delivery including non-viral vectors and cell-based TRAIL therapy. In order to sensitize the tumor cells to TRAIL-induced apoptosis, combination therapy of TRAIL DNA with other drugs by the codelivery methods for yielding a synergistic antitumor efficacy is summarized. The opportunities and challenges of TRAIL-based gene delivery and therapy are discussed. |
| WOS关键词 | APOPTOSIS-INDUCING LIGAND ; MESENCHYMAL STEM-CELLS ; PROSTATE-CANCER CELLS ; DEATH RECEPTOR 5 ; CO-DELIVERY ; IN-VIVO ; MEDIATED APOPTOSIS ; ANTITUMOR-ACTIVITY ; TUMORICIDAL ACTIVITY ; PROTEIN EXPRESSION |
| 资助项目 | 973 Program, China[2014CB931900] ; NFSC[81673382] ; NFSC[81521005] ; Strategic Priority Research Program of CAS[XDA12050307] ; National Special Project for Significant New Drugs Development[2018ZX09711002-010-002] ; CAS Scientific Research and Equipment Development Project[YZ201437] ; Fudan-SIMM Joint Research Fund[FU-SIMM20174009] |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000494974700001 |
| 出版者 | NATURE PUBLISHING GROUP |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/281941]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Huang, Yong-zhuo |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Shanghai Univ, Coll Sci, Shanghai 200444, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhong, Hui-hai,Wang, Hui-yuan,Li, Jian,et al. TRAIL-based gene delivery and therapeutic strategies[J]. ACTA PHARMACOLOGICA SINICA,2019,40(11):1373-1385. |
| APA | Zhong, Hui-hai,Wang, Hui-yuan,Li, Jian,&Huang, Yong-zhuo.(2019).TRAIL-based gene delivery and therapeutic strategies.ACTA PHARMACOLOGICA SINICA,40(11),1373-1385. |
| MLA | Zhong, Hui-hai,et al."TRAIL-based gene delivery and therapeutic strategies".ACTA PHARMACOLOGICA SINICA 40.11(2019):1373-1385. |
入库方式： OAI收割
来源：上海药物研究所
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