Rosanortriterpene C, a 3,24-Dinor-2,4-seco-ursane Triterpene from the Fruits of Rosa laevigata var. leiocapus
文献类型：期刊论文
| 作者 | Tian, Yunong2,3; Feng, Lu4; Li, Bailin2; Hu, Juanjuan2; Xie, Jindan2; Xiao, Wenjing2; Nie, Linghui1; Wu, Jiewei2 |
| 刊名 | CHEMICAL & PHARMACEUTICAL BULLETIN
 |
| 出版日期 | 2019-11-01 |
| 卷号 | 67期号:11页码:1255-1258 |
| 关键词 | ursane-type nortriterpene oleanane-type nortriterpene Rosa laevigata var. leiocapus anti-inflammatory |
| ISSN号 | 0009-2363 |
| 通讯作者 | Nie, Linghui(nielinghui1213@163.com) ; Wu, Jiewei(wujiewei@gzucm.edu.cn) |
| 英文摘要 | One new 3,24-dinor-2,4-seco-ursane triterpene, rosanortriterpene C (1), together with four known compounds including 24-norursane-type nortriterpenes (2-3), 24-noroleanane-type nortriterpene (4), ursanetype triterpene (5), was isolated from the fruits of Rosa laevigata var. leiocapus. The new structure was elucidated through comprehensive spectroscopic analysis, including one dimensional (1D) and 2D NMR data, as well as electrospray ionization high resolution (HR-ESI) MS and IR spectrometry. Compounds 1-5 showed moderate anti-inflammatory activities against the production of nitric oxide (NO) in RAW264.7 cells stimulated by lipopolysaccharide (LPS) with IC50 values of 10.35 +/- 0.92, 14.28 +/- 1.20, 5.04 +/- 1.43, 29.29 +/- 3.64, and 14.37 +/- 0.59 mu M, respectively. |
| 资助项目 | State key Laboratory of Drug Research[SIMM1803KF-09] |
| WOS研究方向 | Pharmacology & Pharmacy ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000494055100013 |
| 出版者 | PHARMACEUTICAL SOC JAPAN |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/281965]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Nie, Linghui; Wu, Jiewei |
| 作者单位 | 1.Guangdong Second Prov Gen Hosp, Guangdong Tradit Med & Sports Injury Rehabil Res, Guangzhou 510317, Guangdong, Peoples R China 2.Guangzhou Univ Chinese Med, Math Engn Acad Chinese Med, Guangzhou 510006, Guangdong, Peoples R China 3.Guangzhou Univ, Sch Life Sci, Guangzhou 510006, Guangdong, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Materia Med, 555 Zu Chong Zhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tian, Yunong,Feng, Lu,Li, Bailin,et al. Rosanortriterpene C, a 3,24-Dinor-2,4-seco-ursane Triterpene from the Fruits of Rosa laevigata var. leiocapus[J]. CHEMICAL & PHARMACEUTICAL BULLETIN,2019,67(11):1255-1258. |
| APA | Tian, Yunong.,Feng, Lu.,Li, Bailin.,Hu, Juanjuan.,Xie, Jindan.,...&Wu, Jiewei.(2019).Rosanortriterpene C, a 3,24-Dinor-2,4-seco-ursane Triterpene from the Fruits of Rosa laevigata var. leiocapus.CHEMICAL & PHARMACEUTICAL BULLETIN,67(11),1255-1258. |
| MLA | Tian, Yunong,et al."Rosanortriterpene C, a 3,24-Dinor-2,4-seco-ursane Triterpene from the Fruits of Rosa laevigata var. leiocapus".CHEMICAL & PHARMACEUTICAL BULLETIN 67.11(2019):1255-1258. |
入库方式： OAI收割
来源：上海药物研究所
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