中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 上海药物研究所
  3. 中国科学院上海药物研究所
  4. 新药研究国家重点实验室
Engineering Nanoparticles to Reprogram the Tumor Immune Microenvironment for Improved Cancer Immunotherapy

文献类型：期刊论文

作者Saeed, Madiha2,3; Gao, Jing2,3; Shi, Yang4,5; Lammers, Twan1,4,5,6; Yu, Haijun2,3,7
刊名THERANOSTICS
出版日期2019
卷号9期号:26页码:7981-8000
关键词Cancer immunotherapy nanoparticles immune microenvironment programming antitumor immune response
ISSN号1838-7640
DOI10.7150/thno.37568
通讯作者Yu, Haijun(hjyu@simm.ac.cn)
英文摘要Immunotherapy is rapidly maturing towards extensive clinical use. However, it does not work well in large patient populations because of an immunosuppressed microenvironment and limited reinvigoration of antitumor immunity. The tumor microenvironment is a complex milieu in which the principles of physiology and anatomy are defied and which is considered an immune-privileged site promoting T cell exhaustion. Tremendous research interest exists in developing nanoparticle-based approaches to modulate antitumor immune responses. The increasing use of immunotherapies in the clinic requires robust programming of immune cells to boost antitumor immunity. This review summarizes recent advances in the engineering of nanoparticles for improved anticancer immunotherapy. It discusses emerging nanoparticle-based approaches for the modulation of tumor cells and immune cells, such as dendritic cells, T cells and tumor-associated macrophages, with the intention to overcome challenges currently faced in the clinic. Furthermore, this review describes potentially curative combination therapeutic approaches to provoke effective tumor antigen-specific immune responses. We foresee a future in which improvement in patient's surveillance will become a mainstream practice.
WOS关键词IMMUNOGENIC CELL-DEATH ; HEMATOPOIETIC STEM-CELLS ; DENDRITIC CELLS ; T-CELLS ; CALRETICULIN EXPOSURE ; ANTICANCER CHEMOTHERAPY ; CHECKPOINT BLOCKADE ; CD47 BLOCKADE ; DELIVERY ; THERAPY
资助项目National Natural Science Foundation of China[31671024] ; National Natural Science Foundation of China[51873228] ; National Natural Science Foundation of China[31622025] ; National Natural Science Foundation of China[81521005] ; CAS President's International Fellowship Initiative Program[2019PB0023]
WOS研究方向Research & Experimental Medicine
语种英语
WOS记录号WOS:000492831200001
出版者IVYSPRING INT PUBL
源URL[http://119.78.100.183/handle/2S10ELR8/281968]  
专题新药研究国家重点实验室
通讯作者Yu, Haijun
作者单位1.Univ Twente, MIRA Inst Biomed Technol & Tech Med, Dept Targeted Therapeut, NL-7500 AE Enschede, Netherlands
2.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
3.Chinese Acad Sci, Ctr Pharmaceut, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
4.Rhein Westfal TH Aachen, Dept Nanomed & Theranost, Inst Expt Mol Imaging, Uniklin RWTH Aachen,Fac Med, D-52074 Aachen, Germany
5.Rhein Westfal TH Aachen, Fac Med, Helmholtz Inst Biomed Engn, D-52074 Aachen, Germany
6.Univ Utrecht, Utrecht Inst Pharmaceut Sci, Dept Pharmaceut, NL-3584 CG Utrecht, Netherlands
7.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Saeed, Madiha,Gao, Jing,Shi, Yang,et al. Engineering Nanoparticles to Reprogram the Tumor Immune Microenvironment for Improved Cancer Immunotherapy[J]. THERANOSTICS,2019,9(26):7981-8000.
APA Saeed, Madiha,Gao, Jing,Shi, Yang,Lammers, Twan,&Yu, Haijun.(2019).Engineering Nanoparticles to Reprogram the Tumor Immune Microenvironment for Improved Cancer Immunotherapy.THERANOSTICS,9(26),7981-8000.
MLA Saeed, Madiha,et al."Engineering Nanoparticles to Reprogram the Tumor Immune Microenvironment for Improved Cancer Immunotherapy".THERANOSTICS 9.26(2019):7981-8000.

入库方式： OAI收割

来源：上海药物研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。