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Acid-activatable Polymeric Drug Delivery Systems for Cancer Therapy

文献类型：期刊论文

作者Gao, Jing2,3; Wang, Wei-qi1; Yu, Hai-jun2,3
刊名ACTA POLYMERICA SINICA
出版日期2019-11-01
卷号50期号:11页码:1156-1166
关键词Nanosized drug delivery system Tumor acidic microenvironment Polymeric nanoparticles Physiological barriers
DOI10.11777/j.issn1000-3304.2019.19133
通讯作者Yu, Hai-jun(hjyu@simm.ac.cn)
英文摘要The polymeric drug delivery systems (DDS) have showed promising potential for improving cancer therapy, which can lengthen the blood circulation and minimize the adverse effect of chemotherapeutics. Despite promising, the therapeutic performance of polymeric-based DDS is affected by a series of physiological barriers, including limited tumor accumulation, restricted tumor penetration, insufficient cellular uptake, and slow drug release inside the tumor cells. It has been well-investigated that there is an acidic microenvironment inside the solid tumors due to the abnormal glucose metabolism of tumor cells. Moreover, the subcellular organelles including endosome and lysosome display much lower acidic pH than that of cytosol. The extracellular and intracellular acidic microenvironments have thus been exploited as both a trigger and target for tumor-targeted drug delivery. In this review article, we summarized our recent advances in developing acid-responsive polymeric DDS by taking the advantage of the acidic microenvironment of tumor tissue and tumor cells. We particularly highlighted the acid-responsive chemical bonds and components employed for constructing the acid-activatable DDS. These acid-activatable nanovectors have been exploited for combating the physiological barriers by surface charge conversion, nanostructure dissociation, and ligand presentation. We also provided a perspective regarding of the challenges and opportunities about clinical translation of the stimuli-activatable DDS.
WOS关键词GENE DELIVERY ; PHOTODYNAMIC THERAPY ; WORMLIKE MICELLES ; TUMOR PENETRATION ; LUNG-CANCER ; PH ; NANOPARTICLES ; RESISTANCE ; DESIGN ; SIRNA
WOS研究方向Polymer Science
语种英语
WOS记录号WOS:000497774600003
出版者SCIENCE PRESS
源URL[http://119.78.100.183/handle/2S10ELR8/282029]  
专题新药研究国家重点实验室
通讯作者Yu, Hai-jun
作者单位1.Nantong Univ, Sch Pharm, Nantong 226001, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Gao, Jing,Wang, Wei-qi,Yu, Hai-jun. Acid-activatable Polymeric Drug Delivery Systems for Cancer Therapy[J]. ACTA POLYMERICA SINICA,2019,50(11):1156-1166.
APA Gao, Jing,Wang, Wei-qi,&Yu, Hai-jun.(2019).Acid-activatable Polymeric Drug Delivery Systems for Cancer Therapy.ACTA POLYMERICA SINICA,50(11),1156-1166.
MLA Gao, Jing,et al."Acid-activatable Polymeric Drug Delivery Systems for Cancer Therapy".ACTA POLYMERICA SINICA 50.11(2019):1156-1166.

入库方式： OAI收割

来源：上海药物研究所

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