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Dynamic modifications of biomacromolecules: mechanism and chemical interventions

文献类型：期刊论文

作者Wang, Chu2; Zou, Peng2; Yang, Caiguang1; Liu, Lei3; Cheng, Liang4; He, Xiaopeng5; Zhang, Liang6; Zhang, Yan7; Jiang, Hualiang1; Chen, Peng R.2
刊名SCIENCE CHINA-LIFE SCIENCES
出版日期2019-11-01
卷号62期号:11页码:1459-1471
关键词chemical biology biomacromolecule dynamic modification modification analysis chemical intervention
ISSN号1674-7305
DOI10.1007/s11427-019-9823-1
通讯作者Jiang, Hualiang(hljiang@simm.ac.cn) ; Chen, Peng R.(pengchen@pku.edu.cn)
英文摘要Biological macromolecules (proteins, nucleic acids, polysaccharides, etc.) are the building blocks of life, which constantly undergo chemical modifications that are often reversible and spatial-temporally regulated. These dynamic properties of chemical modifications play fundamental roles in physiological processes as well as pathological changes of living systems. The Major Research Project (MRP) funded by the National Natural Science Foundation of China (NSFC)-"Dynamic modifications of biomacromolecules: mechanism and chemical interventions" aims to integrate cross-disciplinary approaches at the interface of chemistry, life sciences, medicine, mathematics, material science and information science with the following goals: (i) developing specific labeling techniques and detection methods for dynamic chemical modifications of biomacromolecules, (ii) analyzing the molecular mechanisms and functional relationships of dynamic chemical modifications of biomacromolecules, and (iii) exploring biomacromolecules and small molecule probes as potential drug targets and lead compounds.
WOS关键词POSTTRANSLATIONAL MODIFICATIONS ; PROTEIN LIPIDATION ; DNA METHYLATION ; TARGET ; IDENTIFICATION ; GLYCOSYLATION ; CHEMISTRY ; HEALTH ; DYRK2 ; P53
WOS研究方向Life Sciences & Biomedicine - Other Topics
语种英语
WOS记录号WOS:000501478800003
出版者SCIENCE PRESS
源URL[http://119.78.100.183/handle/2S10ELR8/282088]  
专题中国科学院上海药物研究所
通讯作者Jiang, Hualiang; Chen, Peng R.
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
2.Peking Univ, Coll Chem & Mol Engn, Beijing 100871, Peoples R China
3.Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China
4.Chinese Acad Sci, Inst Chem, Beijing 100190, Peoples R China
5.East China Univ Sci & Technol, Sch Chem & Mol Engn, Shanghai 200237, Peoples R China
6.Shanghai Jiao Tong Univ, Dept Pharmacol & Chem Biol, Sch Med, Shanghai 200025, Peoples R China
7.Natl Nat Sci Fdn China, Beijing 100085, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Chu,Zou, Peng,Yang, Caiguang,et al. Dynamic modifications of biomacromolecules: mechanism and chemical interventions[J]. SCIENCE CHINA-LIFE SCIENCES,2019,62(11):1459-1471.
APA Wang, Chu.,Zou, Peng.,Yang, Caiguang.,Liu, Lei.,Cheng, Liang.,...&Chen, Peng R..(2019).Dynamic modifications of biomacromolecules: mechanism and chemical interventions.SCIENCE CHINA-LIFE SCIENCES,62(11),1459-1471.
MLA Wang, Chu,et al."Dynamic modifications of biomacromolecules: mechanism and chemical interventions".SCIENCE CHINA-LIFE SCIENCES 62.11(2019):1459-1471.

入库方式： OAI收割

来源：上海药物研究所

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