New NO production inhibitors from Hyssopus cuspidatus in LPS-induced RAW264.7 cells
文献类型：期刊论文
| 作者 | Liu, Dan5; Yin, Qiang1; Zhang, Qihua3,4,5; Xiang, Jin5; Ruan, Changlei5; Liu, Huili2; Li, Bo3,4; Zhu, Weiliang3,4 ; Yin, Chun-ping5; Fang, Jinbo5
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| 刊名 | PHYTOCHEMISTRY LETTERS
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| 出版日期 | 2019-12-01 |
| 卷号 | 34页码:91-95 |
| 关键词 | Hyssopus cuspidatus Sesquiterpenes NO production inhibition |
| ISSN号 | 1874-3900 |
| DOI | 10.1016/j.phytol.2019.09.012 |
| 通讯作者 | Yin, Chun-ping(cpyin888@163.com) ; Fang, Jinbo(fangjb@hust.edu.cn) |
| 英文摘要 | Two new sesquiterpenes, including 7-epi-3-eudesmene-1 beta,11-diol (1) and (7S,10R)-11-hydroxy-4,5-seco-guai-1-ene-4-one (2); one new natural product (11-hydroxy-1-oxo-4 beta,5 beta,7 beta,10 beta-eremophilane); (3) and nine known compounds were isolated from the aerial parts of Hyssopus cuspidatus Boriss. Their structures as well as their absolute configurations were elucidated by extensive spectroscopic analyses and quantum chemical calculations. Compounds 1 to 9 were tested to evaluate their inhibitory effects on NO production in LPS-induced RAW264.7 cells. Compounds 5 and 8 exhibited inhibitory effects, with IC50 values of 40.43 and 32.56 mu M, respectively, compared to the positive control (i.e., dexamethasone, IC50 = 70.35 mu M), and compound 4 exhibited a weaker activity, with an IC50 value of 112.56 mu M. |
| WOS关键词 | BIOLOGICAL-ACTIVITY ; TRITERPENES ; CONSTITUENTS |
| 资助项目 | National Natural Science Foundation of China[31000150] ; Chinese Fundamental Research Funds for the Central Universities[HUST2016YXMS145] ; State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics of China[T152602] |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000498702200017 |
| 出版者 | ELSEVIER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/282103]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Yin, Chun-ping; Fang, Jinbo |
| 作者单位 | 1.Xinjiang Uygur Pharmaceut Co Ltd, Urumqi Econ & Technol Dev Zone Toutunhe Dist, 2 Shenyang St, Urumqi 830026, Xinjiang, Peoples R China 2.Chinese Acad Sci, Wuhan Inst Phys & Math, Wuhan 430071, Hubei, Peoples R China 3.Chinese Acad Sci, CAS Key Lab Receptor Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 4.Chinese Acad Sci, Drug Discovery & Design Ctr, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 5.Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Hubei, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Dan,Yin, Qiang,Zhang, Qihua,et al. New NO production inhibitors from Hyssopus cuspidatus in LPS-induced RAW264.7 cells[J]. PHYTOCHEMISTRY LETTERS,2019,34:91-95. |
| APA | Liu, Dan.,Yin, Qiang.,Zhang, Qihua.,Xiang, Jin.,Ruan, Changlei.,...&Fang, Jinbo.(2019).New NO production inhibitors from Hyssopus cuspidatus in LPS-induced RAW264.7 cells.PHYTOCHEMISTRY LETTERS,34,91-95. |
| MLA | Liu, Dan,et al."New NO production inhibitors from Hyssopus cuspidatus in LPS-induced RAW264.7 cells".PHYTOCHEMISTRY LETTERS 34(2019):91-95. |
入库方式： OAI收割
来源：上海药物研究所
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