Current trends in drug metabolism and pharmacokinetics
文献类型：期刊论文
| 作者 | Li, Yuhua7,8; Meng, Qiang9; Yang, Mengbi1; Liu, Dongyang2; Hou, Xiangyu6; Tang, Lan5; Wang, Xin4; Lyu, Yuanfeng1; Chen, Xiaoyan6 ; Liu, Kexin9
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| 刊名 | ACTA PHARMACEUTICA SINICA B
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| 出版日期 | 2019-11-01 |
| 卷号 | 9期号:6页码:1113-1144 |
| ISSN号 | 2211-3835 |
| 关键词 | Pharmacokinetics Drug metabolism Drug-drug interactions Modeling Metabolizing enzymes Transporters Nuclear receptors Noncoding RNAs |
| DOI | 10.1016/j.apsb.2019.10.001 |
| 通讯作者 | Chen, Xiaoyan(xychen@simm.ac.cn) ; Liu, Kexin(liukexin89@163.com) ; Yu, Ai-Ming(aimyu@ucdavis.edu) ; Zuo, Zhong(joanzuo@cuhk.edu.hk) ; Bi, Huichang(bihchang@mail.sysu.edu.cn) |
| 英文摘要 | Pharmacokinetics (PK) is the study of the absorption, distribution, metabolism, and excretion (ADME) processes of a drug. Understanding PK properties is essential for drug development and precision medication. In this review we provided an overview of recent research on PK with focus on the following aspects: (1) an update on drug-metabolizing enzymes and transporters in the determination of PK, as well as advances in xenobiotic receptors and noncoding RNAs (ncRNAs) in the modulation of PK, providing new understanding of the transcriptional and posttranscriptional regulatory mechanisms that result in inter-individual variations in pharmacotherapy; (2) current status and trends in assessing drug-drug interactions, especially interactions between drugs and herbs, between drugs and therapeutic biologics, and microbiota-mediated interactions; (3) advances in understanding the effects of diseases on PK, particularly changes in metabolizing enzymes and transporters with disease progression; (4) trends in mathematical modeling including physiologically-based PK modeling and novel animal models such as CRISPR/Cas9-based animal models for DMPK studies; (5) emerging non-classical xenobiotic metabolic pathways and the involvement of novel metabolic enzymes, especially non-P450s. Existing challenges and perspectives on future directions are discussed, and may stimulate the development of new research models, technologies, and strategies towards the development of better drugs and improved clinical practice. (C) 2019 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V. |
| WOS关键词 | ARYL-HYDROCARBON RECEPTOR ; BLOOD-BRAIN-BARRIER ; ORGANIC ANION TRANSPORTERS ; CHRONIC KIDNEY-DISEASE ; PREGNANE-X-RECEPTOR ; P-GLYCOPROTEIN ; QUANTITATIVE PREDICTION ; CYTOCHROME-P450 ENZYMES ; DOWN-REGULATION ; IN-VIVO |
| 资助项目 | National Natural Science Foundation of China[81573489] ; National Natural Science Foundation of China[81522047] ; National Natural Science Foundation of China[81730103] ; National Natural Science Foundation of China[81320108027] ; National Natural Science Foundation of China[81660618] ; National Natural Science Foundation of China[81773808] ; National Key Research and Development Program (China)[2017YFE0109900] ; National Key Research and Development Program (China)[2017YFC0909303] ; 111 project (China)[B16047] ; Key Laboratory Foundation of Guangdong Province (China)[2017B030314030] ; Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program (China)[2017BT01Y093] ; National Engineering and Technology Research Center for New drug Druggability Evaluation (Seed Program of Guangdong Province, China)[2017B090903004] ; Natural Science Foundation of Guangdong (China)[2017A030311018] ; Natural Science Foundation of Guangdong (China)[2015A030313124] ; National Institutes of Health (USA)[R01CA225958] ; National Institutes of Health (USA)[R01GM113888] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| 出版者 | INST MATERIA MEDICA, CHINESE ACAD MEDICAL SCIENCES |
| WOS记录号 | WOS:000500912700003 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/282136]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Chen, Xiaoyan; Liu, Kexin; Yu, Ai-Ming; Zuo, Zhong; Bi, Huichang |
| 作者单位 | 1.Chinese Univ Hong Kong, Sch Pharm, Hong Kong, Peoples R China 2.Peking Univ, Hosp 3, Drug Clin Trial Ctr, Beijing 100191, Peoples R China 3.Univ Calif Davis, Sch Med, Sacramento, CA 95817 USA 4.East China Normal Univ, Sch Life Sci, Shanghai 200241, Peoples R China 5.Southern Med Univ, Sch Pharmaceut Sci, Guangzhou 510515, Guangdong, Peoples R China 6.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 7.Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510275, Guangdong, Peoples R China 8.Nanchang Univ, Affiliated Hosp 1, Nanchang 330006, Jiangxi, Peoples R China 9.Dalian Med Univ, Coll Pharm, Dalian 116044, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Yuhua,Meng, Qiang,Yang, Mengbi,et al. Current trends in drug metabolism and pharmacokinetics[J]. ACTA PHARMACEUTICA SINICA B,2019,9(6):1113-1144. |
| APA | Li, Yuhua.,Meng, Qiang.,Yang, Mengbi.,Liu, Dongyang.,Hou, Xiangyu.,...&Bi, Huichang.(2019).Current trends in drug metabolism and pharmacokinetics.ACTA PHARMACEUTICA SINICA B,9(6),1113-1144. |
| MLA | Li, Yuhua,et al."Current trends in drug metabolism and pharmacokinetics".ACTA PHARMACEUTICA SINICA B 9.6(2019):1113-1144. |
入库方式： OAI收割
来源：上海药物研究所
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