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Lycodine-type alkaloids from Lycopodiastrum casuarinoides and their acetylcholinesterase inhibitory activity

文献类型：期刊论文

作者Feng, Zheling2; Chen, Shixin3; Wang, Wei4; Feng, Lu1,5; Dong, Yanyan6; Zou, Yiping6; Ke, Changqiang1,5; Tang, Chunping1,5; Yao, Sheng1,5; Zhang, Haiyan4
刊名FITOTERAPIA
出版日期2019-11-01
卷号139页码:7
关键词Lycopodiastrum casuarinoides Lycopodiaceae Lycodine-type alkaloids TD-DFT ECD
ISSN号0367-326X
DOI10.1016/j.fitote.2019.104378
通讯作者Gan, Lishe(lsgan@zju.edu.cn) ; Ye, Yang(yye@simm.ac.cn) ; Lin, Ligen(ligenl@um.edu.mo)
英文摘要Five previously undescribed lycodine-type alkaloids, named huperzine Y (1), 8,15-epoxy-N-demethylhuperzinine (2), 7-hydroxyl-huperzinine (3), huperzine Z (4), and huperzine D N-oxide (5), were isolated from the aerial parts and roots of Lycopodiastrum casuarinoides (Lycopodiaceae), along with ten known analogues. The structures of the new compounds were elucidated by means of spectroscopic technique (IR, UV, MS and NMR). The absolute configurations of the new compounds were established on the basis of comparison of their experimental and TD-DFT (time-dependent density functional theory) calculated ECD spectra. Moreover, all the isolates were evaluated for acetylcholinesterase (AChE) inhibitory activity. Only huperzine C showed moderate activity, with an IC50 value of 0.525 +/- 0.140 mu M, which was comparable with the positive control, huperzine A (IC50 = 0.143 +/- 0.029 mu M).
WOS关键词ALZHEIMERS-DISEASE ; HUPERZINE
资助项目Research Fund of the Research Fund of University of Macau, Macao[MYRG2017-00109-ICMS] ; Research Fund of the Research Fund of University of Macau, Macao[MYRG2018-00037-ICMS] ; National Natural Science Foundation of China, China[81573305] ; National Natural Science Foundation of China, China[81872754] ; Strategic Priority Research Program of the Chinese Academy of Sciences, China[XDA12040106] ; International Partnership Program of Chinese Academy of Sciences, China[153631KYSB20160004] ; State Key Laboratory of Drug Research, China[SIMM1803KF-16]
WOS研究方向Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000501622300028
出版者ELSEVIER
源URL[http://119.78.100.183/handle/2S10ELR8/282184]  
专题新药研究国家重点实验室
通讯作者Gan, Lishe; Ye, Yang; Lin, Ligen
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, Nat Prod Chem Dept, Shanghai 201203, Peoples R China
2.Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Taipa 999078, Macao, Peoples R China
3.Zhejiang Univ, Coll Pharmaceut Sci, Hangzhou 310007, Zhejiang, Peoples R China
4.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China
5.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Long Res, Shanghai 201203, Peoples R China
6.Yichun Univ, Coll Chem & Bioengn, Yichun 336000, Jiangxi, Peoples R China
7.Shanghai Tech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China
推荐引用方式
GB/T 7714		 Feng, Zheling,Chen, Shixin,Wang, Wei,et al. Lycodine-type alkaloids from Lycopodiastrum casuarinoides and their acetylcholinesterase inhibitory activity[J]. FITOTERAPIA,2019,139:7.
APA Feng, Zheling.,Chen, Shixin.,Wang, Wei.,Feng, Lu.,Dong, Yanyan.,...&Lin, Ligen.(2019).Lycodine-type alkaloids from Lycopodiastrum casuarinoides and their acetylcholinesterase inhibitory activity.FITOTERAPIA,139,7.
MLA Feng, Zheling,et al."Lycodine-type alkaloids from Lycopodiastrum casuarinoides and their acetylcholinesterase inhibitory activity".FITOTERAPIA 139(2019):7.

入库方式： OAI收割

来源：上海药物研究所

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