中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 上海药物研究所
  3. 中国科学院上海药物研究所
  4. 新药研究国家重点实验室
New triterpenoids and PTP1B inhibitory constituents of Pseudolarix amabilis

文献类型：期刊论文

作者Lei, Chun1; Huang, Qing-Hua1; Zhao, Ting1; Wang, Pei-Pei2; Li, Jing-Ya2; Li, Jia2; Hou, Ai-Jun1
刊名FITOTERAPIA
出版日期2019-11-01
卷号139页码:7
关键词Pseudolarix amabilis Triterpenoids Pseudolarins A-F Protein tyrosine phosphatase 1B
ISSN号0367-326X
DOI10.1016/j.fitote.2019.104414
通讯作者Hou, Ai-Jun(ajhou@shmu.edu.cn)
英文摘要Six new triterpenoids, pseudolarins A-F (1-6), were isolated from the twigs of Pseudolarix amabilis, together with four known triterpenoids (7-10) and five known diterpenoids (11-15). Their structures were determined by extensive spectroscopic analysis, and the absolute configuration of 1 was assigned by single-crystal X-ray diffraction. Compound 1 is a 3,4:9,10-diseco-cycloartane triterpenoid possessing an unprecedented 5/5/7/6/5/6/5 ring system. Compounds 1, 5, 7, 9-11, and 13 showed inhibition against protein tyrosine phosphatase 1B (PTP1B) in vitro.
WOS关键词DITERPENOIDS ; KAEMPFERI
资助项目National Natural Science Foundation of China[81222045] ; National Natural Science Foundation of China[21672040] ; Drug Innovation Major Project of China[2018ZX09735001-002-006]
WOS研究方向Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000501622300034
出版者ELSEVIER
源URL[http://119.78.100.183/handle/2S10ELR8/282188]  
专题新药研究国家重点实验室
通讯作者Hou, Ai-Jun
作者单位1.Fudan Univ, Sch Pharm, State Key Lab Med Neurobiol, Shanghai 201203, Peoples R China
2.Chinese Acad Sci, Natl Ctr Drug Screening, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Lei, Chun,Huang, Qing-Hua,Zhao, Ting,et al. New triterpenoids and PTP1B inhibitory constituents of Pseudolarix amabilis[J]. FITOTERAPIA,2019,139:7.
APA Lei, Chun.,Huang, Qing-Hua.,Zhao, Ting.,Wang, Pei-Pei.,Li, Jing-Ya.,...&Hou, Ai-Jun.(2019).New triterpenoids and PTP1B inhibitory constituents of Pseudolarix amabilis.FITOTERAPIA,139,7.
MLA Lei, Chun,et al."New triterpenoids and PTP1B inhibitory constituents of Pseudolarix amabilis".FITOTERAPIA 139(2019):7.

入库方式： OAI收割

来源：上海药物研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。