Spiroalanfurantones A-D, Four Eudesmanolide-Furan Sesquiterpene Adducts with a Pentacyclic 6/6/5/5/5 Skeleton from Inula helenium
文献类型：期刊论文
| 作者 | Cai, You-Sheng1; Wu, Zi1; Wang, Jian-Rong2 ; Zheng, Xiao-Qin1; Xu, Jie1; Qiu, Guofu1; Yu, Jianqing1
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| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2019-12-06 |
| 卷号 | 21期号:23页码:9478-9482 |
| ISSN号 | 1523-7060 |
| DOI | 10.1021/acs.orglett.9b03676 |
| 通讯作者 | Yu, Jianqing(jqyu@whu.edu.cn) |
| 英文摘要 | Spiroalanfurantones A-D (1-4), four eudesmanolide-furan sesquiterpene adducts with an unprecedented pentacyclic 6/6/5/5/5 skeleton, were isolated from the roots of Inula helenium. Their structures were elucidated by spectroscopic data analysis and single-crystal X-ray diffraction analysis. The plausible biosynthetic pathway for 1-4 is presented. Bioassay showed that compounds 1 and 2 significantly inhibited nitric oxide production in lipopolysaccharide-induced RAW264.7 macrophages with IC50 values of 17.3 and 9.5 mu M, respectively. |
| WOS关键词 | LACTONE DIMERS ; ROOTS ; CYTOTOXICITY |
| 资助项目 | National Natural Science Foundation of China[31670348] ; National Natural Science Foundation of China[31970369] ; National Natural Science Foundation of China[81973201] ; National Key R&D Program of China[2018YFC0311002] ; Fundamental Research Funds for the Central Universities[2042019kf0228] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000502163300042 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/282199]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Yu, Jianqing |
| 作者单位 | 1.Wuhan Univ, Inst TCM & Nat Prod, Sch Pharmaceut Sci, Wuhan 430071, Hubei, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Pharmaceut Analyt & Solid State Chem Res Ctr, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Cai, You-Sheng,Wu, Zi,Wang, Jian-Rong,et al. Spiroalanfurantones A-D, Four Eudesmanolide-Furan Sesquiterpene Adducts with a Pentacyclic 6/6/5/5/5 Skeleton from Inula helenium[J]. ORGANIC LETTERS,2019,21(23):9478-9482. |
| APA | Cai, You-Sheng.,Wu, Zi.,Wang, Jian-Rong.,Zheng, Xiao-Qin.,Xu, Jie.,...&Yu, Jianqing.(2019).Spiroalanfurantones A-D, Four Eudesmanolide-Furan Sesquiterpene Adducts with a Pentacyclic 6/6/5/5/5 Skeleton from Inula helenium.ORGANIC LETTERS,21(23),9478-9482. |
| MLA | Cai, You-Sheng,et al."Spiroalanfurantones A-D, Four Eudesmanolide-Furan Sesquiterpene Adducts with a Pentacyclic 6/6/5/5/5 Skeleton from Inula helenium".ORGANIC LETTERS 21.23(2019):9478-9482. |
入库方式： OAI收割
来源：上海药物研究所
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