Practical synthesis of Vistusertib (AZD2014), an ATP competitive mTOR inhibitor
文献类型：期刊论文
| 作者 | Shen, Guobing2; Liu, Miaoqing2; Lu, Jianjun2; Meng, Tao1
|
| 刊名 | TETRAHEDRON LETTERS
 |
| 出版日期 | 2019-12-26 |
| 卷号 | 60期号:52页码:3 |
| 关键词 | Vistusertib AZD2014 mTOR inhibitor 3-Acetylbenzoic acid |
| ISSN号 | 0040-4039 |
| DOI | 10.1016/j.tetlet.2019.151333 |
| 通讯作者 | Lu, Jianjun(lujianjunktz@tyut.edu.cn) ; Meng, Tao(tmeng@sibs.ac.cn) |
| 英文摘要 | Vistusertib (AZD2014) is a potent, selective inhibitor of mTOR kinase. Prompted by its fascinating biological activity, an efficient and practical synthesis of Vistusertib has been developed from 3-acetylbenzoic acid through six steps in 48% overall yield. (C) 2019 Elsevier Ltd. All rights reserved. |
| WOS关键词 | DISCOVERY |
| 资助项目 | National Science & Technology Major Project Key New Drug Creation and Manufacturing Program, China[2014ZX09508001] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000504526500007 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/282202]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Lu, Jianjun; Meng, Tao |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, 555 Chong Zhi Rd, Shanghai 201203, Peoples R China 2.Taiyuan Univ Technol, Key Lab Coal Sci & Technol, Minist Educ & Shanxi Prov, Taiyuan 030024, Shanxi, Peoples R China |
| 推荐引用方式 GB/T 7714 | Shen, Guobing,Liu, Miaoqing,Lu, Jianjun,et al. Practical synthesis of Vistusertib (AZD2014), an ATP competitive mTOR inhibitor[J]. TETRAHEDRON LETTERS,2019,60(52):3. |
| APA | Shen, Guobing,Liu, Miaoqing,Lu, Jianjun,&Meng, Tao.(2019).Practical synthesis of Vistusertib (AZD2014), an ATP competitive mTOR inhibitor.TETRAHEDRON LETTERS,60(52),3. |
| MLA | Shen, Guobing,et al."Practical synthesis of Vistusertib (AZD2014), an ATP competitive mTOR inhibitor".TETRAHEDRON LETTERS 60.52(2019):3. |
入库方式： OAI收割
来源：上海药物研究所
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