Enantiomeric pairs of meroterpenoids from Rhododendron fastigiatum
文献类型：期刊论文
| 作者 | Huang Guang-Hui1; Lei Chun1; Zhu Ke-Xin2; Li Jing-Ya2 ; Li Jia2; Hou Ai-Jun1
|
| 刊名 | CHINESE JOURNAL OF NATURAL MEDICINES
 |
| 出版日期 | 2019-12-01 |
| 卷号 | 17期号:12页码:963-969 |
| 关键词 | Rhododendron fastigiatum Meroterpenoid enantiomers Protein tyrosine phosphatase 1B |
| ISSN号 | 2095-6975 |
| 通讯作者 | Lei Chun(chunlei@fudan.edu.cn) ; Hou Ai-Jun(ajhou@shmu.edu.cn) |
| 英文摘要 | Five pairs of optically pure meroterpenoid enantiomers (1a/1b-5a/5b) and two known compounds (6 and 7) were isolated from Rhododendron fastigiatum. Compounds 1a/1b-5a/5b were resolved from naturally scalemic mixtures by chiral HPLC. Their structures were elucidated by spectroscopic methods, X-ray crystallographic experiments, and ECD analyses. Compounds 1a/1b, 2a/2b, 3b, 4a/4b, and 5a/5b were new meroterpenoids with different polycyclic systems. Two enantiomeric pairs (2a/2b and 3a/3b), 6, and 7 exhibited inhibitory effects on protein tyrosine phosphatase 1B (PTP1B) in vitro. |
| WOS关键词 | DERIVATIVES ; (+/-)-RHODONOIDS ; DITERPENOIDS ; INHIBITORS ; LEAVES ; PTP1B |
| 资助项目 | National Natural Science Foundation of China[81222045] ; Fudan-SIMM Joint Research Fund[FU-SIMM20181011] |
| WOS研究方向 | Integrative & Complementary Medicine ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000504330400014 |
| 出版者 | CHINESE JOURNAL NATURAL MEDICINES |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/282209]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Lei Chun; Hou Ai-Jun |
| 作者单位 | 1.Fudan Univ, Sch Pharm, State Key Lab Med Neurobiol, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Natl Ctr Drug Screening, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Huang Guang-Hui,Lei Chun,Zhu Ke-Xin,et al. Enantiomeric pairs of meroterpenoids from Rhododendron fastigiatum[J]. CHINESE JOURNAL OF NATURAL MEDICINES,2019,17(12):963-969. |
| APA | Huang Guang-Hui,Lei Chun,Zhu Ke-Xin,Li Jing-Ya,Li Jia,&Hou Ai-Jun.(2019).Enantiomeric pairs of meroterpenoids from Rhododendron fastigiatum.CHINESE JOURNAL OF NATURAL MEDICINES,17(12),963-969. |
| MLA | Huang Guang-Hui,et al."Enantiomeric pairs of meroterpenoids from Rhododendron fastigiatum".CHINESE JOURNAL OF NATURAL MEDICINES 17.12(2019):963-969. |
入库方式： OAI收割
来源：上海药物研究所
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