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A Concise and Efficient Approach to 2,6-Disubstituted 4-Fluoropyrimidines from alpha-CF3 Aryl Ketones

文献类型：期刊论文

作者Liu, Fangran1,2; Zhang, Xiaofei1; Qian, Qun2; Yang, Chunhao1
刊名SYNTHESIS-STUTTGART
出版日期2020-01-17
卷号52期号:2页码:273-280
关键词fluoropyrimidine alpha-CF3 aryl ketone metal-free mild conditions
ISSN号0039-7881
DOI10.1055/s-0039-1690248
通讯作者Qian, Qun(qianqun@shu.edu.cn) ; Yang, Chunhao(chyang@simm.ac.cn)
英文摘要Herein, a concise and efficient protocol to synthesize a series of 2,6-disubstituted 4-fluoropyrimidines as universal and useful building blocks in medicinal chemistry is reported. From readily accessible alpha-CF3 aryl ketones and different amidine hydrochlorides, this method provides a very practical approach to this kind of compounds under mild conditions with good to excellent yields.
WOS关键词PYRIMIDINE ; INHIBITORS ; FLUORINE ; DESIGN ; CHEMISTRY ; DISCOVERY
资助项目National Natural Science Foundation of China[81872722] ; Science and Technology Commission of Shanghai Municipality[18431907100] ; Shanghai Sailing Program[17YF1423400] ; SKLDR/Shanghai Institute of Materia Medica (SIMM)[SIMM1601ZZ-03]
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000502820600011
出版者GEORG THIEME VERLAG KG
源URL[http://119.78.100.183/handle/2S10ELR8/282219]  
专题新药研究国家重点实验室
通讯作者Qian, Qun; Yang, Chunhao
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China
2.Shanghai Univ, Dept Chem, 99 Shang Da Rd, Shanghai 200444, Peoples R China
推荐引用方式
GB/T 7714		 Liu, Fangran,Zhang, Xiaofei,Qian, Qun,et al. A Concise and Efficient Approach to 2,6-Disubstituted 4-Fluoropyrimidines from alpha-CF3 Aryl Ketones[J]. SYNTHESIS-STUTTGART,2020,52(2):273-280.
APA Liu, Fangran,Zhang, Xiaofei,Qian, Qun,&Yang, Chunhao.(2020).A Concise and Efficient Approach to 2,6-Disubstituted 4-Fluoropyrimidines from alpha-CF3 Aryl Ketones.SYNTHESIS-STUTTGART,52(2),273-280.
MLA Liu, Fangran,et al."A Concise and Efficient Approach to 2,6-Disubstituted 4-Fluoropyrimidines from alpha-CF3 Aryl Ketones".SYNTHESIS-STUTTGART 52.2(2020):273-280.

入库方式： OAI收割

来源：上海药物研究所

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