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Phytochemical and biological studies on rare and endangered plants endemic to China. Part XV. Structurally diverse diterpenoids and sesquiterpenoids from the vulnerable conifer Pseudotsuga sinensis

文献类型：期刊论文

作者Huang, Ting3; Ying, Sheng-Hui3; Li, Jing-Ya2; Chen, Hao-Wei3; Zang, Yi2; Wang, Wen-Xuan1; Li, Jia2; Xiong, Juan3; Hu, Jin-Feng3
刊名PHYTOCHEMISTRY
出版日期2020
卷号169页码:14
关键词Pseudotsuga sinensis dode Pinaceae Rare and endangered plants (REPs) Degraded diterpenoids Pseudosinins ATP-Citrate lyase (ACL)
ISSN号0031-9422
DOI10.1016/j.phytochem.2019.112184
通讯作者Xiong, Juan(jxiong@fudan.edu.cn) ; Hu, Jin-Feng(jfhu@fudan.edu.cn)
英文摘要An extensive phytochemical investigation on the chemical constituents from the needles and twigs of the vulnerable conifer Pseudotsuga sinensis yielded 19 diterpenoids and 21 sesquiterpenoids with various carbocyclic skeletons. Among them, 13 (named pseudosinins A-M, resp.) were undescribed compounds. Their structures with absolute configurations were characterized by a combination of spectroscopic methods, calculated and experimental electronic circular dichroism (ECD) data, quantum chemical calculations of the chemical shifts, and single crystal X-ray diffraction analyses. In particular, an array of labdane-derived norditerpenoids with C-19-, C-18-, and C-16-skeletons, and related drimane-type sesquitepenoids with C-15- and C-13-skeletons were found in the title plant. The possible biogenetic relationships of these degraded terpenoids were briefly discussed. Among the isolates, pseudosinin D, cis-communic acid, and 4 beta,15-dihydroxy-19-norabieta-8,11,13-trien-7-one showed moderate inhibitory activities against the enzyme ATP-citrate lyase (ACL), a potential drug target for the treatment of hyperlipidemia and hypercholesterolemia.
WOS关键词ATP-CITRATE LYASE ; NF-KAPPA-B ; OPLOPANAX JAPONICUS NAKAI ; ABSOLUTE-CONFIGURATION ; PINUS-DABESHANENSIS ; NATURAL-PRODUCTS ; STEM BARK ; CONSTITUENTS ; DERIVATIVES ; TERPENOIDS
资助项目NSFC[81773599] ; NSFC[21937002] ; NSFC[21772025] ; MOST[2019ZX09735002-005]
WOS研究方向Biochemistry & Molecular Biology ; Plant Sciences
语种英语
WOS记录号WOS:000502890200017
出版者PERGAMON-ELSEVIER SCIENCE LTD
源URL[http://119.78.100.183/handle/2S10ELR8/282224]  
专题新药研究国家重点实验室
通讯作者Xiong, Juan; Hu, Jin-Feng
作者单位1.South Cent Univ Nationalities, Sch Pharmaceut Sci, Wuhan 430074, Hubei, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
3.Fudan Univ, Sch Pharm, Dept Nat Prod Chem, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Huang, Ting,Ying, Sheng-Hui,Li, Jing-Ya,et al. Phytochemical and biological studies on rare and endangered plants endemic to China. Part XV. Structurally diverse diterpenoids and sesquiterpenoids from the vulnerable conifer Pseudotsuga sinensis[J]. PHYTOCHEMISTRY,2020,169:14.
APA Huang, Ting.,Ying, Sheng-Hui.,Li, Jing-Ya.,Chen, Hao-Wei.,Zang, Yi.,...&Hu, Jin-Feng.(2020).Phytochemical and biological studies on rare and endangered plants endemic to China. Part XV. Structurally diverse diterpenoids and sesquiterpenoids from the vulnerable conifer Pseudotsuga sinensis.PHYTOCHEMISTRY,169,14.
MLA Huang, Ting,et al."Phytochemical and biological studies on rare and endangered plants endemic to China. Part XV. Structurally diverse diterpenoids and sesquiterpenoids from the vulnerable conifer Pseudotsuga sinensis".PHYTOCHEMISTRY 169(2020):14.

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来源：上海药物研究所

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