Polycyclic furanobutenolide-derived norditerpenoids from the South China Sea soft corals Sinularia scabra and Sinularia polydactyla with immunosuppressive activity
文献类型:期刊论文
作者 | Cui, Wan-Xiang4,5; Yang, Min1,5; Li, Heng1,6; Li, Song-Wei2,5; Yao, Li-Gong5; Li, Geng1,5; Tang, Wei1,6![]() ![]() |
刊名 | BIOORGANIC CHEMISTRY
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出版日期 | 2020 |
卷号 | 94页码:8 |
关键词 | Norditerpenoids Sinularia Absolute configuration Immunosuppressive activity |
ISSN号 | 0045-2068 |
DOI | 10.1016/j.bioorg.2019.103350 |
通讯作者 | Liang, Lin-Fu(lianglinfu@aliyun.com) ; Guo, Yue-Wei(ywguo@simm.ac.cn) |
英文摘要 | One new polycyclic furanobutenolide-derived norcembranoid, xiguscabrolide H (1), together with eleven known related norditerpenoids 2-12 were isolated from South China Sea soft corals Sinularia scabra and S. polydactyla, respectively. Among them, compounds 1, 6, 8, and 12 were discovered from the former species, while compounds 2-5,7, and 9-11 were obtained from the latter species. The structure of new compound 1 was elucidated by extensive spectroscopic analysis and by the comparison with the reported data. With the assistance of time-dependent density functional theory electronic circular dichroism (TDDFT-ECD) calculations, its absolute configuration was determined. Moreover, the absolute stereostructures of the known compounds 3, 4, and 9-12, of which only relative configurations were assigned, were established for the first time by X-Ray diffraction analysis and TDDFT-ECD calculations, respectively. In bioassay, several isolates exhibited potent inhibitory effects on the ConA-induced T lymphocytes and/or LPS-induced B lymphocytes proliferation. |
WOS关键词 | YONAROLIDE ; CHEMISTRY ; GENUS |
资助项目 | National Key Research and Development Program of China[2018YFC0310903] ; National Natural Science Foundation of China (NSFC)[81520108028] ; National Natural Science Foundation of China (NSFC)[21672230] ; National Natural Science Foundation of China (NSFC)[41876194] ; National Natural Science Foundation of China (NSFC)[81603022] ; NSFC/CNRS joint project[81811530284] ; NSFC-Shandong Joint Fund for Marine Science Research Centers[U1606403] ; Drug Innovation Major Project[2018ZX09711-001-001-009] ; SKLDR/ SIMM Project[SIMM1903ZZ-04] |
WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
语种 | 英语 |
WOS记录号 | WOS:000505596300009 |
出版者 | ACADEMIC PRESS INC ELSEVIER SCIENCE |
源URL | [http://119.78.100.183/handle/2S10ELR8/282254] ![]() |
专题 | 新药研究国家重点实验室 |
通讯作者 | Liang, Lin-Fu; Guo, Yue-Wei |
作者单位 | 1.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 2.Nanjing Univ Chinese Med, Nanjing 210023, Jiangsu, Peoples R China 3.Cent South Univ Forestry & Technol, Coll Mat Sci & Engn, 498 South Shaoshan Rd, Changsha 410004, Hunan, Peoples R China 4.Binzhou Med Univ, Sch Pharm, 346 Guanhai Rd, Yantai 264003, Peoples R China 5.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China 6.Chinese Acad Sci, Shanghai Inst Mat Med, Lab Immunopharmacol, Shanghai 201203, Peoples R China |
推荐引用方式 GB/T 7714 | Cui, Wan-Xiang,Yang, Min,Li, Heng,et al. Polycyclic furanobutenolide-derived norditerpenoids from the South China Sea soft corals Sinularia scabra and Sinularia polydactyla with immunosuppressive activity[J]. BIOORGANIC CHEMISTRY,2020,94:8. |
APA | Cui, Wan-Xiang.,Yang, Min.,Li, Heng.,Li, Song-Wei.,Yao, Li-Gong.,...&Guo, Yue-Wei.(2020).Polycyclic furanobutenolide-derived norditerpenoids from the South China Sea soft corals Sinularia scabra and Sinularia polydactyla with immunosuppressive activity.BIOORGANIC CHEMISTRY,94,8. |
MLA | Cui, Wan-Xiang,et al."Polycyclic furanobutenolide-derived norditerpenoids from the South China Sea soft corals Sinularia scabra and Sinularia polydactyla with immunosuppressive activity".BIOORGANIC CHEMISTRY 94(2020):8. |
入库方式: OAI收割
来源:上海药物研究所
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