Fabrication of beta-cyclodextrin and sialic acid copolymer by single pot reaction to site specific drug delivery
文献类型：期刊论文
| 作者 | Singh, Parbeen2,3; Ren, Xiaohong3; He, Yaping2,3; Wu, Li3; Wang, Caifen3; Li, Haiyan3 ; Singh, Vikramjeet1,3; Zhang, Jiwen2,3
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| 刊名 | ARABIAN JOURNAL OF CHEMISTRY
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| 出版日期 | 2020 |
| 卷号 | 13期号:1页码:1397-1405 |
| 关键词 | Sialic acid Cyclodextrin Supramolecular copolymer Site specific drug delivery |
| ISSN号 | 1878-5352 |
| DOI | 10.1016/j.arabjc.2017.11.011 |
| 通讯作者 | Singh, Parbeen() ; Singh, Vikramjeet(singh.simm@outlook.com) ; Zhang, Jiwen(jwzhang@simm.ac.cn) |
| 英文摘要 | The fabrication of supramolecular host in combination biomolecules is an interesting idea in modern drug delivery for development of new polymer with advanced chemical and biological properties. Herein, hyper-crosslinked copolymer was fabricated from beta-cyclodextrin (beta-CD) and sialic acid (SA) monomers, which can be undoublty considered as a new class of copolymer. The as-synthesized copolymer has complexation properties, which could cover the drug within the structure and deliver to the site of action. The well-known inclusion capability of beta-CD and targeted efficacy of SA made it more appropriate for targeted drug delivery. The copolymer was characterized using a wide range of spectroscopic and microscopic techniques such as synchrotron radiation based FTIR spectroscopy (SR-FTIR), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), and powder X-ray diffraction (PXRD). The surface area and porosity were calculated by using Nitrogen adsorption method. Doxorubicin (Dox) was selected as a model drug to evaluate the loading efficiency and cellular penetration ability of the copolymer. The copolymer showed high adsorption towards Dox with no significant cytotoxic effects on HeLa cells as proved by cell viability assay. High cellular penetration of Dox loaded copolymer was also recorded by confocal microscopy when compared with free Dox in HeLa cells at 4 h of exposure. Thus, beta-CD-SA copolymer could be a useful carrier for targeted drug delivery of cancer and has the potential for further investigation in viral and nervous disease due to the targeting ability of SA. (C) 2017 Production and hosting by Elsevier B.V. on behalf of King Saud University. |
| WOS关键词 | ANTITUMOR-ACTIVITY ; NANOSPONGES ; SYSTEM ; NANOPARTICLES ; PEGYLATION ; POLYMERS ; DNA |
| 资助项目 | National Natural Science Foundation of China[81430087] ; National Science and Technology Major Project[2017ZX09101001-006] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000505076000103 |
| 出版者 | ELSEVIER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/282298]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Singh, Parbeen; Singh, Vikramjeet; Zhang, Jiwen |
| 作者单位 | 1.Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Delivery Syst, 501 Haike Rd, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Singh, Parbeen,Ren, Xiaohong,He, Yaping,et al. Fabrication of beta-cyclodextrin and sialic acid copolymer by single pot reaction to site specific drug delivery[J]. ARABIAN JOURNAL OF CHEMISTRY,2020,13(1):1397-1405. |
| APA | Singh, Parbeen.,Ren, Xiaohong.,He, Yaping.,Wu, Li.,Wang, Caifen.,...&Zhang, Jiwen.(2020).Fabrication of beta-cyclodextrin and sialic acid copolymer by single pot reaction to site specific drug delivery.ARABIAN JOURNAL OF CHEMISTRY,13(1),1397-1405. |
| MLA | Singh, Parbeen,et al."Fabrication of beta-cyclodextrin and sialic acid copolymer by single pot reaction to site specific drug delivery".ARABIAN JOURNAL OF CHEMISTRY 13.1(2020):1397-1405. |
入库方式： OAI收割
来源：上海药物研究所
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