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Phytochemical and biological studies on rare and endangered plants endemic to China. Part XIV. Structurally diverse terpenoids from the twigs and needles of the endangered plant Picea brachytyla

文献类型：期刊论文

作者Jiang, Wei3; Xiong, Juan3; Zang, Yi1; Li, Junmin4; Osman, Ezzat E. A.2,3; Li, Jing-Ya; Zhou, Yu-Bo1; Li, Jia1; Hua, Jin-Feng3,4
刊名PHYTOCHEMISTRY
出版日期2020
卷号169页码:11
关键词Picea brachytyla (Franch.) E.Pritz. Pinaceae Endangered plant Terpenoids Brachytylins ATP citrate lyase (ACL) SHP2 tyrosine phosphatase
ISSN号0031-9422
DOI10.1016/j.phytochem.2019.112161
通讯作者Li, Jia(jli@simm.ac.cn) ; Hua, Jin-Feng(jfhu@fudan.edu.cn)
英文摘要A phytochemical investigation on the MeOH extract of the twigs and needles of the endangered plant Picea brachytyla led to the isolation and characterization of thirty-eight structurally diverse terpenoids. Seven of these molecules are previously undescribed, including three abietane-type (brachytylins A-C) and one labdane-type (brachytylin D) diterpenoids, an unseparated C-24 epimeric mixture of cycloartane-type triterpenoids (brachytylins E/F, ratio: 1:1), and a rare rearranged 12(1 -> 6)-abeo-megastigmane glycoside (brachytylins G). Their structures and absolute configurations were determined by extensive spectroscopic (e.g., detailed 2D NMR and ECD) methods and/or X-ray diffraction analyses. All the isolates were evaluated for their inhibitory activities against the adenosine triphosphate (ATP)-citrate lyase (ACL) and the Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2). Among them, abiesadine J showed inhibitory effect against ACL, displaying an IC50 value of 17 mu M. 3S,23R-Dihydroxycycloart-24-en-26-oic acid exhibited inhibitory effect on SHP2, with an IC50 value of 19 mu M. Meanwhile, 3R*,23S*-dihydroxycycloart-24-en-26-oic acid was found to have inhibitory effects against both ACL and SHP2, with IC50 values of 16 and 12 mu M, respectively.
WOS关键词ABIETANE DITERPENOIDS ; NATURAL-PRODUCTS ; STEM BARK ; CONSTITUENTS ; DERIVATIVES ; LEAVES ; TRITERPENOIDS ; INHIBITORS ; GLYCOSIDES ; DRUGS
资助项目NSFC[21937002] ; NSFC[81773599] ; NSFC[21772025] ; STCSM grant[17430742200] ; National Science and Technology Major Project for New Drug Research and Development of MOST[2019ZX09735002-005]
WOS研究方向Biochemistry & Molecular Biology ; Plant Sciences
语种英语
WOS记录号WOS:000502890200011
出版者PERGAMON-ELSEVIER SCIENCE LTD
源URL[http://119.78.100.183/handle/2S10ELR8/282339]  
专题新药研究国家重点实验室
通讯作者Li, Jia; Hua, Jin-Feng
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
2.Theodor Bilharz Res Inst, Lab Med Chem, Giza 12411, Egypt
3.Fudan Univ, Sch Pharm, Dept Nat Prod Chem, Shanghai 201203, Peoples R China
4.Taizhou Univ, Zhejiang Prov Key Lab Plant Evolutionary Ecol & C, Taizhou 318000, Zhejiang, Peoples R China
推荐引用方式
GB/T 7714		 Jiang, Wei,Xiong, Juan,Zang, Yi,et al. Phytochemical and biological studies on rare and endangered plants endemic to China. Part XIV. Structurally diverse terpenoids from the twigs and needles of the endangered plant Picea brachytyla[J]. PHYTOCHEMISTRY,2020,169:11.
APA Jiang, Wei.,Xiong, Juan.,Zang, Yi.,Li, Junmin.,Osman, Ezzat E. A..,...&Hua, Jin-Feng.(2020).Phytochemical and biological studies on rare and endangered plants endemic to China. Part XIV. Structurally diverse terpenoids from the twigs and needles of the endangered plant Picea brachytyla.PHYTOCHEMISTRY,169,11.
MLA Jiang, Wei,et al."Phytochemical and biological studies on rare and endangered plants endemic to China. Part XIV. Structurally diverse terpenoids from the twigs and needles of the endangered plant Picea brachytyla".PHYTOCHEMISTRY 169(2020):11.

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来源：上海药物研究所

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