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alpha-Mangostin remodels visceral adipose tissue inflammation to ameliorate age-related metabolic disorders in mice

文献类型：期刊论文

作者Li, Dan1,4; Liu, Qianyu1; Lu, Xiuqiang5; Li, Zhengqiu3; Wang, Chunming1; Leung, Chung-Hang1; Wang, Yitao1; Peng, Cheng4; Lin, Ligen1,2
刊名AGING-US
出版日期2019-12-15
卷号11期号:23页码:11084-11110
ISSN号1945-4589
关键词alpha-mangostin aging adiposity adipose tissue inflammation macrophage
DOI10.18632/aging.102512
通讯作者Peng, Cheng(pengchengchengdu@126.com) ; Lin, Ligen(ligenl@um.edu.mo)
英文摘要Low-grade chronic adipose tissue inflammation contributes to the onset and development of aging-related insulin resistance and type 2 diabetes. In the current study, alpha-mangostin, a xanthone isolated from mangosteen (Garcinia mangastana), was identified to ameliorate lipopolysaccharides-induced acute adipose tissue inflammation in mice, by reducing the expression of pro-inflammatory cytokines and chemokines. In a cohort of young (3 months) and old (18-20 months) mice, alpha-mangostin mitigated aging-associated adiposity, hyperlipidemia, and insulin resistance. Further study showed that alpha-mangostin alleviated aging-related adipose tissue inflammation by reducing macrophage content and shifting pro-inflammatory macrophage polarization. Moreover, alpha-mangostin protected the old mice against liver injury through suppressing the secretion of microRNA-155-5p from macrophages. The above results demonstrated that alpha-mangostin represents a new scaffold to alleviate adipose tissue inflammation, which might be a novel candidate to treat aging-related metabolic disorders.
WOS关键词KAPPA-B PATHWAY ; INSULIN-RESISTANCE ; HIGH-FAT ; ANTIINFLAMMATORY ACTIVITY ; HEPATIC STEATOSIS ; 3T3-L1 ADIPOCYTES ; IN-VITRO ; OBESITY ; MICRORNA-155 ; MACROPHAGES
资助项目Science and Technology Development Fund, Macao SAR[FDCT 0031/2019/A1] ; Research Fund of University of Macau[MYRG2017-00109-ICMS] ; Research Fund of University of Macau[MYRG201800037-ICMS] ; National Natural Science Foundation of China[81872754] ; National Natural Science Foundation of China[81630101] ; National Natural Science Foundation of China[51503037] ; National Natural Science Foundation of China[81891012] ; State Key Laboratory of Drug Research[SIMM1803KF-16] ; China Postdoctoral Science Foundation[00809403]
WOS研究方向Cell Biology ; Geriatrics & Gerontology
语种英语
出版者IMPACT JOURNALS LLC
WOS记录号WOS:000503237600022
源URL[http://119.78.100.183/handle/2S10ELR8/282353]  
专题新药研究国家重点实验室
通讯作者Peng, Cheng; Lin, Ligen
作者单位1.Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Taipa, Macao, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai, Peoples R China
3.Jinan Univ, Sch Pharm, Guangzhou, Guangdong, Peoples R China
4.Chengdu Univ Tradit Chinese Med, Sch Pharm, State Key Lab Southwestern Characterist Chinese M, Chengdu, Sichuan, Peoples R China
5.Fujian Normal Univ, Fuqing Branch, Fuzhou, Fujian, Peoples R China
推荐引用方式
GB/T 7714		 Li, Dan,Liu, Qianyu,Lu, Xiuqiang,et al. alpha-Mangostin remodels visceral adipose tissue inflammation to ameliorate age-related metabolic disorders in mice[J]. AGING-US,2019,11(23):11084-11110.
APA Li, Dan.,Liu, Qianyu.,Lu, Xiuqiang.,Li, Zhengqiu.,Wang, Chunming.,...&Lin, Ligen.(2019).alpha-Mangostin remodels visceral adipose tissue inflammation to ameliorate age-related metabolic disorders in mice.AGING-US,11(23),11084-11110.
MLA Li, Dan,et al."alpha-Mangostin remodels visceral adipose tissue inflammation to ameliorate age-related metabolic disorders in mice".AGING-US 11.23(2019):11084-11110.

入库方式： OAI收割

来源：上海药物研究所

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