Palladium-Catalysed C(sp(3))-H Glycosylation for the Synthesis of C-Alkyl Glycoamino Acids
文献类型：期刊论文
| 作者 | Liu, Yichu1,2,3; Wang, Yibing2,3; Dai, Wenhao2,3; Huang, Wei2,3; Li, Yingxia1; Liu, Hong2,3
|
| 刊名 | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
 |
| 出版日期 | 2020-01-29 |
| 页码 | 5 |
| 关键词 | alpha-amino acids C(sp(3))-H activation C-alkyl glycosides diastereoselectivity palladium |
| ISSN号 | 1433-7851 |
| DOI | 10.1002/anie.201914184 |
| 通讯作者 | Li, Yingxia(liyx417@fudan.edu.cn) ; Liu, Hong(hliu@simm.ac.cn) |
| 英文摘要 | We have developed a highly efficient and practical approach for palladium-catalyzed trifluoroacetate-promoted N-quinolylcarboxamide-directed glycosylation of inert beta-C(sp(3))-H bonds of N-phthaloyl alpha-amino acids with glycals under mild conditions. For the first time, C(sp(3))-H activation for glycosylation was achieved to build C-alkyl glycosides. This method facilitates the synthesis of various beta-substituted C-alkyl glycoamino acids and offers a tool for glycopeptide synthesis. |
| WOS关键词 | COUPLING REACTIONS ; SGLT2 INHIBITORS ; ARYL ; GLYCOSIDES ; FUNCTIONALIZATION ; OLIGOSACCHARIDES ; CARBOHYDRATE ; STRATEGIES ; ARYLATION ; DESIGN |
| 资助项目 | National Natural Science Foundation of China[21632008] ; National Natural Science Foundation of China[21672231] ; National Natural Science Foundation of China[21877118] ; National Natural Science Foundation of China[81773576] ; National Natural Science Foundation of China[81620108027] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDA12040107] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDA12040201] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000509767900001 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/282430]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Li, Yingxia; Liu, Hong |
| 作者单位 | 1.Fudan Univ, Sch Pharm, Dept Med Chem, Shanghai 201203, Peoples R China 2.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Key Lab Receptor Res, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Yichu,Wang, Yibing,Dai, Wenhao,et al. Palladium-Catalysed C(sp(3))-H Glycosylation for the Synthesis of C-Alkyl Glycoamino Acids[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2020:5. |
| APA | Liu, Yichu,Wang, Yibing,Dai, Wenhao,Huang, Wei,Li, Yingxia,&Liu, Hong.(2020).Palladium-Catalysed C(sp(3))-H Glycosylation for the Synthesis of C-Alkyl Glycoamino Acids.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,5. |
| MLA | Liu, Yichu,et al."Palladium-Catalysed C(sp(3))-H Glycosylation for the Synthesis of C-Alkyl Glycoamino Acids".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020):5. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。