The enantioselective construction of trifluoromethylated quaternary stereocenters via the Rh-catalyzed asymmetric dehydrated arylation of unprotected hemiaminals
文献类型：期刊论文
| 作者 | Sun, Yu-Tuo1,2; Zhu, Dong-Xing1,2; Rao, Xiaofeng3,4; Xu, Ming-Hua1,2,3,4
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| 刊名 | ORGANIC CHEMISTRY FRONTIERS
 |
| 出版日期 | 2020-01-21 |
| 卷号 | 7期号:2页码:340-344 |
| ISSN号 | 2052-4129 |
| DOI | 10.1039/c9qo01203f |
| 通讯作者 | Xu, Ming-Hua(xumh@sustech.edu.cn) |
| 英文摘要 | A method for the highly enantioselective Rh-catalyzed dehydrated arylation of unprotected hemiaminals has been developed, and provided a series of chiral benzosultams bearing trifluoromethylated quaternary stereocenters in high yields with excellent enantioselectivities (up to 99% ee). The synthetic utility was further demonstrated by the facile enantioselective construction of a HIV-1 inhibitor molecule. |
| WOS关键词 | CHIRAL DIENE LIGANDS ; OLEFIN LIGANDS ; ORGANOBORON REAGENTS ; KETIMINES SYNTHESIS ; ARYLBORONIC ACIDS ; PHOSPHITE-OLEFIN ; SULFUR-OLEFINS ; ACCESS ; EFFICIENT ; ACTIVATION |
| 资助项目 | National Science & Technology Major Project Key New Drug Creation and Manufacturing Program, China[2018ZX09711002-006] ; National Natural Science Foundation of China[81521005] ; National Natural Science Foundation of China[21472205] ; National Natural Science Foundation of China[21325209] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000508568000013 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/282439]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Xu, Ming-Hua |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chongzhi Rd, Shanghai 201203, Peoples R China 2.Univ Chinese Acad Sci, Sch Pharm, 555 Zu Chongzhi Rd, Shanghai 201203, Peoples R China 3.Southern Univ Sci & Technol, Shenzhen Grubbs Inst, 1088 Xueyuan Blvd, Shenzhen 518055, Peoples R China 4.Southern Univ Sci & Technol, Dept Chem, 1088 Xueyuan Blvd, Shenzhen 518055, Peoples R China |
| 推荐引用方式 GB/T 7714 | Sun, Yu-Tuo,Zhu, Dong-Xing,Rao, Xiaofeng,et al. The enantioselective construction of trifluoromethylated quaternary stereocenters via the Rh-catalyzed asymmetric dehydrated arylation of unprotected hemiaminals[J]. ORGANIC CHEMISTRY FRONTIERS,2020,7(2):340-344. |
| APA | Sun, Yu-Tuo,Zhu, Dong-Xing,Rao, Xiaofeng,&Xu, Ming-Hua.(2020).The enantioselective construction of trifluoromethylated quaternary stereocenters via the Rh-catalyzed asymmetric dehydrated arylation of unprotected hemiaminals.ORGANIC CHEMISTRY FRONTIERS,7(2),340-344. |
| MLA | Sun, Yu-Tuo,et al."The enantioselective construction of trifluoromethylated quaternary stereocenters via the Rh-catalyzed asymmetric dehydrated arylation of unprotected hemiaminals".ORGANIC CHEMISTRY FRONTIERS 7.2(2020):340-344. |
入库方式： OAI收割
来源：上海药物研究所
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