An activatable near-infrared fluorescent probe for methylglyoxal imaging in Alzheimer's disease mice
文献类型：期刊论文
| 作者 | Dang, Yijing2; Wang, Fengyang2; Li, Lingling2; Lai, Yi2; Xu, Zhiai2; Xiong, Zhi1; Zhang, Ao1 ; Tian, Yang2; Ding, Chunyong1; Zhang, Wen2
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| 刊名 | CHEMICAL COMMUNICATIONS
 |
| 出版日期 | 2020-01-16 |
| 卷号 | 56期号:5页码:707-710 |
| ISSN号 | 1359-7345 |
| DOI | 10.1039/c9cc08265d |
| 通讯作者 | Xu, Zhiai(zaxu@chem.ecnu.edu.cn) ; Ding, Chunyong(chding@simm.ac.cn) ; Zhang, Wen(wzhang@chem.ecnu.edu.cn) |
| 英文摘要 | Visual detection of the methylglyoxal (MGO) level in the brain is critical for understanding its role in the onset and progression of AD. Herein, we disclosed a NIR fluorescent probe, DBTPP, for detecting MGO by utilizing a thiadiazole-fused o-phenylene-diamine moiety as a MGO-specific sensing unit. DBTPP exhibits a series of distinct advantages, such as NIR emission, high selectivity and sensitivity, excellent acid-stability, and a huge off-on ratio. The probe could accurately monitor both exogenous and endogenous MGO variations in SH-SY5Y cells. Besides, it was able to image the endogenous MGO in a transgenic AD mouse model successfully, suggesting the great potential of MGO as a biomarker for early AD diagnosis. |
| WOS关键词 | GLYCATION ; PHASE |
| 资助项目 | National Natural Science Foundation of China[21675055] ; National Natural Science Foundation of China[81402790] ; National Natural Science Foundation of China[21775046] ; National Natural Science Foundation of China[21635003] ; Personalized Medicines-Molecular Signature-based Drug Discovery and Development'' of Strategic Priority Research Program of the Chinese Academy of Sciences[XDA12020320] ; National Science & Techonolgy Major Project Key New Drug Creation and Manufacturing Program, China[2018ZX09711002] ; State Key Laboratory of Drug Research of the Chinese Academy of Sciences[SIMM1903KF-13] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| 出版者 | ROYAL SOC CHEMISTRY |
| WOS记录号 | WOS:000507866200035 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/282451]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Xu, Zhiai; Ding, Chunyong; Zhang, Wen |
| 作者单位 | 1.Chinese Acad Sci, CAS Key Lab Receptor Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 2.East China Normal Univ, Sch Chem & Mol Engn, Shanghai 200241, Peoples R China |
| 推荐引用方式 GB/T 7714 | Dang, Yijing,Wang, Fengyang,Li, Lingling,et al. An activatable near-infrared fluorescent probe for methylglyoxal imaging in Alzheimer's disease mice[J]. CHEMICAL COMMUNICATIONS,2020,56(5):707-710. |
| APA | Dang, Yijing.,Wang, Fengyang.,Li, Lingling.,Lai, Yi.,Xu, Zhiai.,...&Zhang, Wen.(2020).An activatable near-infrared fluorescent probe for methylglyoxal imaging in Alzheimer's disease mice.CHEMICAL COMMUNICATIONS,56(5),707-710. |
| MLA | Dang, Yijing,et al."An activatable near-infrared fluorescent probe for methylglyoxal imaging in Alzheimer's disease mice".CHEMICAL COMMUNICATIONS 56.5(2020):707-710. |
入库方式： OAI收割
来源：上海药物研究所
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