Bioluminescence imaging of carbon monoxide in living cells based on a selective deiodination reaction
文献类型：期刊论文
| 作者 | Wang, Anni1; Li, Xuewei1; Ju, Yong1; Chen, Dongying2 ; Lu, Jianzhong1
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| 刊名 | ANALYST
 |
| 出版日期 | 2020-01-21 |
| 卷号 | 145期号:2页码:550-556 |
| ISSN号 | 0003-2654 |
| DOI | 10.1039/c9an02107h |
| 通讯作者 | Lu, Jianzhong(jzlu@shmu.edu.cn) |
| 英文摘要 | d-Luciferin is a popular bioluminescent substrate of luciferase in the presence of ATP. It is used in luciferase-based bioluminescence imaging and cell-based high-throughput screening applications. Herein, the iodination of d-luciferin was undertaken and explored as a bioluminescence probe without the need for light excitation to sensitively trace and image carbon monoxide (CO) in liver cancer cells. The bioluminescent probe (7 '-iodo-luciferin) exhibited excellent selectivity for CO detection in vitro. This new probe could image exogenous and endogenous CO in the luciferase-transfected cancer cells. This new probe might be used for evaluating the roles of CO in various biological processes. |
| WOS关键词 | CONGESTIVE-HEART-FAILURE ; IN-VIVO ; HEME ; OXYGENASE-1 ; HOMEOSTASIS ; PROBE |
| 资助项目 | Natural Science Foundation of China[21675030] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000508560800021 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/282458]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Lu, Jianzhong |
| 作者单位 | 1.Fudan Univ, Sch Pharm, 826 Zhangheng Rd, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Anni,Li, Xuewei,Ju, Yong,et al. Bioluminescence imaging of carbon monoxide in living cells based on a selective deiodination reaction[J]. ANALYST,2020,145(2):550-556. |
| APA | Wang, Anni,Li, Xuewei,Ju, Yong,Chen, Dongying,&Lu, Jianzhong.(2020).Bioluminescence imaging of carbon monoxide in living cells based on a selective deiodination reaction.ANALYST,145(2),550-556. |
| MLA | Wang, Anni,et al."Bioluminescence imaging of carbon monoxide in living cells based on a selective deiodination reaction".ANALYST 145.2(2020):550-556. |
入库方式： OAI收割
来源：上海药物研究所
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