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Silicone elastomer gel impregnated with 20(S)-protopanaxadiol-loaded nanostructured lipid carriers for ordered diabetic ulcer recovery

文献类型：期刊论文

作者Sun, Di1,3; Guo, Shi-yan2; Yang, Li1,3; Wang, Ya-ru1,3; Wei, Xiao-hui1,3; Song, Sha2; Yang, Yi-wei2; Gan, Yong2; Wang, Zheng-tao1,3
刊名ACTA PHARMACOLOGICA SINICA
出版日期2020
卷号41期号:1页码:119-128
关键词diabetic ulcer ordered recovery scarless wound healing 20 (S)-protopanaxadiol nanostructured lipid carrier silicone elastomer
ISSN号1671-4083
DOI10.1038/s41401-019-0288-7
通讯作者Wang, Zheng-tao(ztwang@shutcm.edu.cn)
英文摘要Inefficient diabetic ulcer healing and scar formation remain a challenge worldwide, owing to a series of disordered and dynamic biological events that occur during the process of healing. A functional wound dressing that is capable of promoting ordered diabetic wound recovery is eagerly anticipated. In this study, we designed a silicone elastomer with embedded 20(S)-protopanaxadiol-loaded nanostructured lipid carriers (PPD-NS) to achieve ordered recovery in scarless diabetic ulcer healing. The nanostructured lipid carriers were prepared through an emulsion evaporation-solidification method and then incorporated into a network of silicone elastomer to form a unique nanostructured lipid carrier-enriched gel formulation. Interestingly, the PPD-NS showed excellent in vitro anti-inflammatory and proangiogenic activity. Moreover, in diabetic mice with full-thickness skin excision wound, treatment with PPD-NS significantly promoted in vivo scarless wound healing through suppressing inflammatory infiltration in the inflammatory phase, promoting angiogenesis during the proliferation phase, and regulating collagen deposition in the remodeling phase. Hence, this study demonstrates that the developed PPD-NS could facilitate ordered diabetic wound recovery via multifunctional improvement during different wound-healing phases. This novel approach could be promising for scarless diabetic wound healing.
WOS关键词KELOID SCARS ; MIGRATION ; SKIN ; PROLIFERATION ; NANOPARTICLES ; BIOMARKERS ; SCAFFOLDS ; DELIVERY ; RUBBER ; BFGF
资助项目National Natural Science Foundation of China[81530096] ; National Natural Science Foundation of China[81573588]
WOS研究方向Chemistry ; Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000505540800013
出版者NATURE PUBLISHING GROUP
源URL[http://119.78.100.183/handle/2S10ELR8/282463]  
专题中国科学院上海药物研究所
通讯作者Wang, Zheng-tao
作者单位1.Shanghai Univ Tradit Chinese Med, Shanghai Key Lab Compound Chinese Med, Inst Chinese Mat Med, Shanghai 201203, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201210, Peoples R China
3.Shanghai Univ Tradit Chinese Med, MOE Key Lab Standardizat Chinese Med, Inst Chinese Mat Med, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Sun, Di,Guo, Shi-yan,Yang, Li,et al. Silicone elastomer gel impregnated with 20(S)-protopanaxadiol-loaded nanostructured lipid carriers for ordered diabetic ulcer recovery[J]. ACTA PHARMACOLOGICA SINICA,2020,41(1):119-128.
APA Sun, Di.,Guo, Shi-yan.,Yang, Li.,Wang, Ya-ru.,Wei, Xiao-hui.,...&Wang, Zheng-tao.(2020).Silicone elastomer gel impregnated with 20(S)-protopanaxadiol-loaded nanostructured lipid carriers for ordered diabetic ulcer recovery.ACTA PHARMACOLOGICA SINICA,41(1),119-128.
MLA Sun, Di,et al."Silicone elastomer gel impregnated with 20(S)-protopanaxadiol-loaded nanostructured lipid carriers for ordered diabetic ulcer recovery".ACTA PHARMACOLOGICA SINICA 41.1(2020):119-128.

入库方式： OAI收割

来源：上海药物研究所

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