Engineering Versatile Nanoparticles for Near-Infrared Light-Tunable Drug Release and Photothermal Degradation of Amyloid beta
文献类型：期刊论文
| 作者 | Lai, Yi1; Zhu, Yingying1; Xu, Zhiai1; Hu, Xianli1; Saeed, Madiha3; Yu, Haijun3 ; Chen, Xingxing2; Liu, Jun2; Zhang, Wen1
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| 刊名 | ADVANCED FUNCTIONAL MATERIALS
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| 出版日期 | 2020-01-28 |
| 页码 | 12 |
| 关键词 | Alzheimer's disease amyloid beta conjugated polymer light-triggered drug release photothermal degradation |
| ISSN号 | 1616-301X |
| DOI | 10.1002/adfm.201908473 |
| 通讯作者 | Xu, Zhiai(zaxu@chem.ecnu.edu.cn) ; Zhang, Wen(wzhang@chem.ecnu.edu.cn) |
| 英文摘要 | Nanomedicines that inhibit/disassemble amyloid beta (A beta) aggregates in Alzheimer's disease (AD) are highly desirable yet remain challenging. Therapeutic efficacy and systemic delivery of reported molecules and nanoparticles (NPs) are hampered by various challenges, including low biocompatibility, off-target toxicity, and lack of specificity. Herein, a versatile NP is designed by integrating high A beta-binding affinity, stimuli-responsive drug release, and photothermal degradation properties for efficient disassembly of A beta. Near-infrared (NIR)-absorbing conjugated polymer PDPP3T-O14 serves as a photothermal core while thermal-responsive polymer 1,2-dipalmitoyl-sn-glycero-3-phosphocholine at the outer layer as the NIR-stimuli gatekeeper. Curcumin, an inhibitor of A beta aggregation, is loaded into the NP with high encapsulation efficiency. The 5-mer beta-sheet breaker peptides LPFFD (Leu-Pro-Phe-Phe-Asp) having high binding affinity toward A beta are further anchored onto the surface of polyethylene glycol-lipid shell for active A beta-targeting. The resultant NPs exhibit good A beta-targeting ability and obvious photothermal dissociation effect together with A beta aggregation-dependent fluorescence detection capability. Upon NIR laser irradiation, entrapped curcumin can be effectively released from the unconsolidated NPs to enhance the anti-amyloid activity. In vitro studies demonstrate that the NPs dramatically lower A beta-induced cytotoxicity of PC12 cells, and therefore show great potential for the application in AD treatment. |
| WOS关键词 | ALZHEIMERS-DISEASE ; GOLD NANORODS ; AGGREGATION ; PEPTIDE ; CURCUMIN ; FIBRILS ; INHIBITION ; THERAPY ; DISSOLUTION ; OLIGOMERS |
| 资助项目 | National Natural Science Foundation of China[21675055] ; National Natural Science Foundation of China[21775046] ; National Natural Science Foundation of China[21635003] ; Fundamental Research Funds for the Central Universities |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:000509589200001 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/282472]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Xu, Zhiai; Zhang, Wen |
| 作者单位 | 1.East China Normal Univ, Sch Chem & Mol Engn, Shanghai 200241, Peoples R China 2.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lai, Yi,Zhu, Yingying,Xu, Zhiai,et al. Engineering Versatile Nanoparticles for Near-Infrared Light-Tunable Drug Release and Photothermal Degradation of Amyloid beta[J]. ADVANCED FUNCTIONAL MATERIALS,2020:12. |
| APA | Lai, Yi.,Zhu, Yingying.,Xu, Zhiai.,Hu, Xianli.,Saeed, Madiha.,...&Zhang, Wen.(2020).Engineering Versatile Nanoparticles for Near-Infrared Light-Tunable Drug Release and Photothermal Degradation of Amyloid beta.ADVANCED FUNCTIONAL MATERIALS,12. |
| MLA | Lai, Yi,et al."Engineering Versatile Nanoparticles for Near-Infrared Light-Tunable Drug Release and Photothermal Degradation of Amyloid beta".ADVANCED FUNCTIONAL MATERIALS (2020):12. |
入库方式： OAI收割
来源：上海药物研究所
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