Structure elucidation and anti-tumor activity in vivo of a polysaccharide from spores of Ganoderma lucidum (Fr.) Karst
文献类型：期刊论文
| 作者 | Fu, Youli3; Shi, Lei1,2,3; Ding, Kan2
|
| 刊名 | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
 |
| 出版日期 | 2019-12-01 |
| 卷号 | 141页码:693-699 |
| 关键词 | Polysaccharide Anti-tumor activity beta-Glucan Structure Ganoderma lucidum |
| ISSN号 | 0141-8130 |
| DOI | 10.1016/j.ijbiomac.2019.09.046 |
| 通讯作者 | Shi, Lei(shilei@tp.edu.sg) |
| 英文摘要 | To explore new anti-tumor constituents in the fungi, a water-soluble polysaccharide, WGLP was obtained from spores of Ganoderma lucidum (Fr.) Karst. The average molecular weight of this polysaccharide was estimated to be 1.5 x 10(4) Da. Monosaccharide composition analysis indicated that it was composed solely of glucose. From methylation analysis, H-1 and C-13 NMR spectroscopy, and periodate oxidation and Smith degradation, it could be concluded that WGLP contained beta-D-glucose residue exclusively, with an average repeating unit of hexasaccharide, having a backbone consisting of (1 -> 3)-beta-D-glucopyranosyl residues, to which the side chain consisting of terminal and (1 -> 6)-beta-D-glucopyranosyl residue is attached at position O-6 of the branching residues. Anti-tumor activity assays in vivo showed that WGLP could significantly inhibit the S180 tumor growth in the mice. Furthermore, no drug-related toxic reactions were observed. It was suggested that WGLP might be a potential anti-tumor agent used in the clinic. (C) 2019 Elsevier B.V. All rights reserved. |
| WOS关键词 | RETICULOENDOTHELIAL SYSTEM ; NEUTRAL POLYSACCHARIDE ; ANTIDIABETES DRUGS ; EDIBLE MUSHROOM ; GLUCAN ; PURIFICATION ; CELL ; CYTOKINES ; FEATURES ; GLYCANS |
| 资助项目 | National Natural Science Foundation of China (NSFC)[30970640] ; Knowledge Innovation Program of the Chinese Academy of Sciences[SIMM0912QN-10] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry ; Polymer Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000506713000072 |
| 出版者 | ELSEVIER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/282494]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Shi, Lei |
| 作者单位 | 1.Temasek Polytech, Sch ofApplied Sci, Singapore 529757, Singapore 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 3.Qufu Normal Univ, Qufu 273165, Shandong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Fu, Youli,Shi, Lei,Ding, Kan. Structure elucidation and anti-tumor activity in vivo of a polysaccharide from spores of Ganoderma lucidum (Fr.) Karst[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2019,141:693-699. |
| APA | Fu, Youli,Shi, Lei,&Ding, Kan.(2019).Structure elucidation and anti-tumor activity in vivo of a polysaccharide from spores of Ganoderma lucidum (Fr.) Karst.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,141,693-699. |
| MLA | Fu, Youli,et al."Structure elucidation and anti-tumor activity in vivo of a polysaccharide from spores of Ganoderma lucidum (Fr.) Karst".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 141(2019):693-699. |
入库方式： OAI收割
来源：上海药物研究所
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