Microenvironment-Responsive Small-Molecule Probe for Pulmonary Fibrosis Detection
文献类型：期刊论文
| 作者 | Dong, Ying3; Li, Xiao-Rong4; Chen, Qi2; Guo, Rui-Ying4; Tang, Bi-Xi1,3; Kan, Wei-Juan1; Zhang, Wei2; Hu, Yongzhou4; Li, Jia1 ; Zang, Yi1
|
| 刊名 | ANALYTICAL CHEMISTRY
 |
| 出版日期 | 2020-01-07 |
| 卷号 | 92期号:1页码:699-706 |
| ISSN号 | 0003-2700 |
| DOI | 10.1021/acs.analchem.9b02264 |
| 通讯作者 | Zang, Yi(yzang@simm.ac.cn) ; Li, Xin(lixin81@zju.edu.cn) |
| 英文摘要 | Pulmonary fibrosis (PF) is a fatal disease with increasing prevalence. Nonradioactive and noninvasive diagnosis of PF at an early stage can improve the prognosis but represents a daunting challenge. Up-regulation of nitric oxide (NO) is a typical microenvironmental feature of PF. Here, we report a small-molecule probe, PNO1, that can fluorogenically sense this microenvironmental feature for PF diagnosis. We demonstrate that PNO1 fluorescence is 6-fold higher in PF-diseased mice lungs than in normal-control groups. In addition to this in vivo result, PNO1 can also be applied in vitro to detect PF-diseased cells and ex vivo to detect PF-diseased tissues from clinical patients. These results highlight PNO1 as a complement to the traditional immunostaining-based methods for PF detection to facilitate quick screening for anti-PF drug candidates. |
| WOS关键词 | NITRIC-OXIDE ; BODIPY DYES ; DISCOVERY ; DISEASE ; DESIGN |
| 资助项目 | National Natural Science Foundations of China[21778048] ; National Natural Science Foundations of China[81673489] ; National Natural Science Foundations of China[31871414] ; Natural Science Foundation of Zhejiang Province, China[LR18H300001] ; Shanghai Science and Technology Development Funds[16430724100] ; National Science & Technology Major Project Key New Drug Creation and Maufacturing Program[2018ZX09711002-010-004] ; National Science & Technology Major Project Key New Drug Creation and Maufacturing Program[2018ZX09711002-007-002] ; Shanghai Key Laboratory of Traditional Chinese Clinical Medicine[14DZ2273200] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| 出版者 | AMER CHEMICAL SOC |
| WOS记录号 | WOS:000506719400056 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/282514]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Zang, Yi; Li, Xin |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Shanghai Univ Tradit Chinese Med, Shuguang Hosp, Dept Pulmonol, Shanghai 201203, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Zhejiang Univ, Coll Pharmaceut Sci, Hangzhou 310058, Peoples R China |
| 推荐引用方式 GB/T 7714 | Dong, Ying,Li, Xiao-Rong,Chen, Qi,et al. Microenvironment-Responsive Small-Molecule Probe for Pulmonary Fibrosis Detection[J]. ANALYTICAL CHEMISTRY,2020,92(1):699-706. |
| APA | Dong, Ying.,Li, Xiao-Rong.,Chen, Qi.,Guo, Rui-Ying.,Tang, Bi-Xi.,...&Li, Xin.(2020).Microenvironment-Responsive Small-Molecule Probe for Pulmonary Fibrosis Detection.ANALYTICAL CHEMISTRY,92(1),699-706. |
| MLA | Dong, Ying,et al."Microenvironment-Responsive Small-Molecule Probe for Pulmonary Fibrosis Detection".ANALYTICAL CHEMISTRY 92.1(2020):699-706. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。