Cinerols, Nitrogenous Meroterpenoids from the Marine Sponge Dysidea cinerea
文献类型：期刊论文
| 作者 | Jiao, Wei-Hua1,2; Li, Jing2; Wang, Dan1; Zhang, Meng-Meng3; Liu, Li-Yun2; Sun, Fan2; Li, Jing-Ya3 ; Capon, Robert J.1; Lin, Hou-Wen2
|
| 刊名 | JOURNAL OF NATURAL PRODUCTS
 |
| 出版日期 | 2019-09-01 |
| 卷号 | 82期号:9页码:2586-2593 |
| ISSN号 | 0163-3864 |
| DOI | 10.1021/acs.jnatprod.9b00471 |
| 通讯作者 | Capon, Robert J.(r.capon@uq.edu.cn) ; Lin, Hou-Wen(franklin67@126.com) |
| 英文摘要 | Eleven new nitrogenous meroterpenoids, cinerols A-K (1-11), were isolated from the marine sponge Dysidea cinerea collected in the South China Sea, and their structures were determined by detailed spectroscopic analysis. Cinerols A (1) and B (2) feature a rare SH-pyrrolo[1,2a]-benzimidazole moiety, while cinerols C-G (3-7) are examples of rare meroterpene benzoxazoles. The cinerols are noncytotoxic to human melanoma A375 cells at the concentration of 32 mu M; however, selected cinerols exhibit moderate inhibitory activity against one or more of protein tyrosine phosphatase 1B, ATP-citrate lyase, and SH2 domain-containing phosphatase-1 with IC50 values of 2.8-27 mu M. |
| WOS关键词 | SESQUITERPENE-QUINONES ; A-C ; AMINOQUINONES ; INHIBITORS ; SKELETONS ; ACIDS |
| 资助项目 | National Natural Science Foundation of China[41576130] ; National Natural Science Foundation of China[U1605221] ; National Key Research and Development Program of China[2018YFC0310901] ; Innovative research team of high-level local universities in Shanghai ; University of Queensland ; Institute for Molecular Bioscience |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000488424000026 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/282597]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Capon, Robert J.; Lin, Hou-Wen |
| 作者单位 | 1.Univ Queensland, Inst Mol Biosci, Div Chem & Struct Biol, St Lucia, Qld 4072, Australia 2.Shanghai Jiao Tong Univ, Sch Med, Ren Ji Hosp,Res Ctr Marine Drugs, Dept Pharm,State Key Lab Oncogenes & Related Gene, Shanghai 200127, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Materia Med, Natl Ctr Drug Screening, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jiao, Wei-Hua,Li, Jing,Wang, Dan,et al. Cinerols, Nitrogenous Meroterpenoids from the Marine Sponge Dysidea cinerea[J]. JOURNAL OF NATURAL PRODUCTS,2019,82(9):2586-2593. |
| APA | Jiao, Wei-Hua.,Li, Jing.,Wang, Dan.,Zhang, Meng-Meng.,Liu, Li-Yun.,...&Lin, Hou-Wen.(2019).Cinerols, Nitrogenous Meroterpenoids from the Marine Sponge Dysidea cinerea.JOURNAL OF NATURAL PRODUCTS,82(9),2586-2593. |
| MLA | Jiao, Wei-Hua,et al."Cinerols, Nitrogenous Meroterpenoids from the Marine Sponge Dysidea cinerea".JOURNAL OF NATURAL PRODUCTS 82.9(2019):2586-2593. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。