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Integrated Proteogenomic Characterization of HBV-Related Hepatocellular Carcinoma

文献类型：期刊论文

作者Gao, Qiang2,3; Zhu, Hongwen4,5; Dong, Liangqing2,3; Shi, Weiwei6; Chen, Ran7,8; Song, Zhijian6; Huang, Chen9; Li, Junqiang6; Dong, Xiaowei6; Zhou, Yanting4,5
刊名CELL
出版日期2019-10-03
卷号179期号:2页码:561-+
ISSN号0092-8674
DOI10.1016/j.cell.2019.08.052
通讯作者Gao, Daming(dgao@sibcb.ac.cn) ; Zhou, Hu(zhouhu@simm.ac.cn) ; Fan, Jia(fan.jia@zs-hospital.sh.cn)
英文摘要We performed the first proteogenomic characterization of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) using paired tumor and adjacent liver tissues from 159 patients. Integrated proteogenomic analyses revealed consistency and discordance among multi-omics, activation status of key signaling pathways, and liver-specific metabolic reprogramming in HBV-related HCC. Proteomic profiling identified three subgroups associated with clinical and molecular attributes including patient survival, tumor thrombus, genetic profile, and the liver-specific proteome. These proteomic subgroups have distinct features in metabolic reprogramming, microenvironment dysregulation, cell proliferation, and potential therapeutics. Two prognostic biomarkers, PYCR2 and ADH1A, related to proteomic subgrouping and involved in HCC metabolic reprogramming, were identified. CTNNB1 and TP53 mutation-associated signaling and metabolic profiles were revealed, among which mutated CTNNB1-associated ALDOA phosphorylation was validated to promote glycolysis and cell proliferation. Our study provides a valuable resource that significantly expands the knowledge of HBV-related HCC and may eventually benefit clinical practice.
WOS关键词VITAMIN-A TOXICITY ; GROWTH-FACTOR-BETA ; SOMATIC MUTATIONS ; PIVOTAL ROLE ; HEPATITIS-B ; HUMAN COLON ; EXPRESSION ; CANCER ; IDENTIFICATION ; CLASSIFICATION
资助项目Strategic Priority Research Program of the Chinese Academy of Sciences[XDA12010202] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDA12030203] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDA12020364] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB19020203] ; National Key Research and Development Program from the Ministry of Science and Technology of China[2017YFC1700200] ; National Key Research and Development Program from the Ministry of Science and Technology of China[2015CB964502] ; National Natural Science Foundation of China[91859105] ; National Natural Science Foundation of China[81790253] ; National Natural Science Foundation of China[91853130] ; Basic Research Project from Technology Commission of Shanghai Municipality[17JC1402200] ; National Science and Technology Major Project[2017ZX10203208-004] ; Shanghai Institute of Materia Medica, Chinese Academy of Science ; U.S. National Cancer Institute's Office of Cancer Clinical Proteomics Research (Clinical Proteomic Tumor Analysis Consortium [CPTAC]) ; Fudan University
WOS研究方向Biochemistry & Molecular Biology ; Cell Biology
语种英语
出版者CELL PRESS
WOS记录号WOS:000488775900022
源URL[http://119.78.100.183/handle/2S10ELR8/282610]  
专题中国科学院上海药物研究所
通讯作者Gao, Daming; Zhou, Hu; Fan, Jia
作者单位1.Yale Univ, Sch Med, Dept Pharmacol, Canc Biol Inst, West Haven, CT 06516 USA
2.Fudan Univ, Zhongshan Hosp, Liver Canc Inst, Dept Liver Surg & Transplantat, 180 Fenglin Rd, Shanghai 200032, Peoples R China
3.Minist Educ, Key Lab Carcinogenesis & Canc Invas, 180 Fenglin Rd, Shanghai 200032, Peoples R China
4.Chinese Acad Sci, Shanghai Inst Mat Med, Dept Analyt Chem, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China
5.Chinese Acad Sci, Shanghai Inst Mat Med, Key Lab Receptor Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China
6.OrigiMed, Shanghai 201114, Peoples R China
7.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Cell Biol, Ctr Excellence Mol Cell Sci, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China
8.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China
9.Baylor Coll Med, Lester & Sue Smith Breast Ctr, Dept Mol & Human Genet, One Baylor Plaza, Houston, TX 77030 USA
10.Fudan Univ, Inst Biomed Sci, Key Lab Med Epigenet & Metab, Shanghai 200032, Peoples R China
推荐引用方式
GB/T 7714		 Gao, Qiang,Zhu, Hongwen,Dong, Liangqing,et al. Integrated Proteogenomic Characterization of HBV-Related Hepatocellular Carcinoma[J]. CELL,2019,179(2):561-+.
APA Gao, Qiang.,Zhu, Hongwen.,Dong, Liangqing.,Shi, Weiwei.,Chen, Ran.,...&Fan, Jia.(2019).Integrated Proteogenomic Characterization of HBV-Related Hepatocellular Carcinoma.CELL,179(2),561-+.
MLA Gao, Qiang,et al."Integrated Proteogenomic Characterization of HBV-Related Hepatocellular Carcinoma".CELL 179.2(2019):561-+.

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来源：上海药物研究所

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