Palladium-catalyzed intramolecular C-H acylation of indoles with thioester
文献类型：期刊论文
| 作者 | Liu, Min1,3; Liu, Yu-Wen1,3; Xu, Hui1,3; Dai, Hui-Xiong1,2,3
|
| 刊名 | TETRAHEDRON LETTERS
 |
| 出版日期 | 2019-09-01 |
| 卷号 | 60期号:39页码:4 |
| 关键词 | C-H acylation Thioester Liebeskind-Srogl reaction Indole-indolone scaffolds |
| ISSN号 | 0040-4039 |
| DOI | 10.1016/j.tetlet.2019.151061 |
| 通讯作者 | Xu, Hui(xuhui2018@simm.ac.cn) ; Dai, Hui-Xiong(hxdai@simm.ac.cn) |
| 英文摘要 | A palladium-catalyzed intramolecular C-H acylation of indole with thioester is described, providing a direct and effective approach for the synthesis of the biologically active indole-indolone scaffolds. The method obviates the need for the prefunctionalized starting materials including organometallic reagents, alkyl halides, and NHP esters in previous metal-catalyzed cross-coupling reaction with thioester. Substrates bearing sensitive halo groups are compatible in the reaction, leaving a functional handle for further structural elaborations. (C) 2019 Elsevier Ltd. All rights reserved. |
| WOS关键词 | THIOL ESTERS ; KETONES ; ALDEHYDES ; EFFICIENT ; ARYL ; BOND |
| 资助项目 | Shanghai Institute of Materia Medica, Chinese Academy of Sciences ; Youth Innovation Promotion Association CAS[2014229] ; Youth Innovation Promotion Association CAS[2018293] ; Institutes for Drug Discovery and Development, Chinese Academy of Sciences[CASIMM0120163006] ; Science and Technology Commission of Shanghai Municipality[17JC1405000] ; Program of Shanghai Academic Research Leader[19XD1424600] ; National Science & Technology Major Project Key New Drug Creation and Manufacturing Program, China[2018ZX09711002-006] ; State Key Laboratory of Natural and Biomimetic Drugs ; NSFC[21772211] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000491304300006 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/282616]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Xu, Hui; Dai, Hui-Xiong |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Key Lab Receptor Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Min,Liu, Yu-Wen,Xu, Hui,et al. Palladium-catalyzed intramolecular C-H acylation of indoles with thioester[J]. TETRAHEDRON LETTERS,2019,60(39):4. |
| APA | Liu, Min,Liu, Yu-Wen,Xu, Hui,&Dai, Hui-Xiong.(2019).Palladium-catalyzed intramolecular C-H acylation of indoles with thioester.TETRAHEDRON LETTERS,60(39),4. |
| MLA | Liu, Min,et al."Palladium-catalyzed intramolecular C-H acylation of indoles with thioester".TETRAHEDRON LETTERS 60.39(2019):4. |
入库方式： OAI收割
来源：上海药物研究所
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