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Targeted photoswitchable imaging of intracellular glutathione by a photochromic glycosheet sensor

文献类型：期刊论文

作者Chai, Xianzhi2,3; Han, Hai-Hao1,2,3; Zang, Yi1; Li, Jia1; He, Xiao-Peng2,3; Zhang, Junji2,3; Tian, He2,3
刊名BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
出版日期2019-10-07
卷号15页码:2380-2389
关键词intracellular GSH molecular switches photochromic glycosheet photoswitchable imaging 2D MnO2 nanosheets
ISSN号1860-5397
DOI10.3762/bjoc.15.230
通讯作者Zang, Yi(yzang@simm.ac.cn) ; Zhang, Junji(zhangjunji@ecust.edu.cn)
英文摘要The development of photochromic fluorescence sensors with dynamic and multiple-signaling is beneficial to the improvement of biosensing/imaging precision. However, elaborate designs with complicated molecular structures are always required to integrate these functions into one molecule. By taking advantages of both redox-active/high loading features of two-dimensional (2D) manganese dioxide (MnO2) and dynamic fluorescence photoswitching of photochromic sensors, we here design a hybrid photochromic MnO2 glycosheet (Glyco-DTE@MnO2) to achieve the photoswitchable imaging of intracellular glutathione (GSH). The photochromic glycosheet manifests significantly turn-on fluorescence and dynamic ON/OFF fluorescence signals in response to GSH, which makes it favorable for intracellular GSH double-check in targeted human hepatoma cell line (HepG2) through the recognition between beta-D-galactoside and asialoglycoprotein receptor (ASGPr) on cell membranes. The dynamic fluorescence signals and excellent selectivity for detection and imaging of GSH ensure the precise determination of cell states, promoting its potential applications in future disease diagnosis and therapy.
WOS关键词FLUORESCENT SENSOR ; IN-VIVO ; MNO2 NANOSHEET ; PROBE ; DIARYLETHENES ; CHEMOTHERAPY ; RECEPTORS ; CELLS ; GSH
资助项目NSFC[21878086] ; NSFC[21420102004] ; Shanghai Municipal Science and Technology Major Project[2018SHZDZX03] ; international cooperation program of Shanghai Science and Technology Committee[17520750100] ; Shanghai Rising-Star Program[19QA1402500]
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000489069100001
出版者BEILSTEIN-INSTITUT
源URL[http://119.78.100.183/handle/2S10ELR8/282625]  
专题新药研究国家重点实验室
通讯作者Zang, Yi; Zhang, Junji
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Natl Ctr Drug Screening, 189 Guo Shoujing Rd, Shanghai 201203, Peoples R China
2.East China Univ Sci & Technol, Sch Chem & Mol Engn, Feringa Nobel Prize Scientist Joint Res Ctr, Joint Int Res Lab Precis Chem & Mol Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China
3.East China Univ Sci & Technol, Sch Chem & Mol Engn, Feringa Nobel Prize Scientist Joint Res Ctr, Key Lab Adv Mat, 130 Meilong Rd, Shanghai 200237, Peoples R China
推荐引用方式
GB/T 7714		 Chai, Xianzhi,Han, Hai-Hao,Zang, Yi,et al. Targeted photoswitchable imaging of intracellular glutathione by a photochromic glycosheet sensor[J]. BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY,2019,15:2380-2389.
APA Chai, Xianzhi.,Han, Hai-Hao.,Zang, Yi.,Li, Jia.,He, Xiao-Peng.,...&Tian, He.(2019).Targeted photoswitchable imaging of intracellular glutathione by a photochromic glycosheet sensor.BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY,15,2380-2389.
MLA Chai, Xianzhi,et al."Targeted photoswitchable imaging of intracellular glutathione by a photochromic glycosheet sensor".BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY 15(2019):2380-2389.

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来源：上海药物研究所

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