Structural optimization and neurotrophic activity evaluation of neurotrophic gentiside derivatives
文献类型：期刊论文
| 作者 | Wang, Zhenkang3; Ma, Chunhua1; Wang, Yujie3; Xiao, Qiang3; Xu, Chenghui2; Li, Yingxia3 |
| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
 |
| 出版日期 | 2019-11-15 |
| 卷号 | 29期号:22页码:6 |
| 关键词 | Gentisides Neurotrophic activity Isosteric replacement Conformational restriction PC 12 cells |
| ISSN号 | 0960-894X |
| DOI | 10.1016/j.bmcl.2019.126685 |
| 通讯作者 | Li, Yingxia(liyx417@fudan.edu.cn) |
| 英文摘要 | C14 alkyl benzoate ABG001, derived from naturally occurring gentisides, was reported to exhibit neurotrophic activity which is similar to NGF (Nerve Growth Factor). In this research, ABG001 was modified by the strategy of isosteric replacement and conformational restriction with the purpose of improving the bioactivity. The cellular neurotrophic activity of those ABG001 derivatives were evaluated, among which 3-hydroxyquinolin-2-(1H)-one A3 and 4-decylphenol ester B7 displayed much better neurotrophic activity compared with ABG001, which highlights the potential of those novel scaffolds for future neurotrophic agent development. |
| WOS关键词 | NEURITE OUTGROWTH ; NEURODEGENERATION |
| 资助项目 | National Natural Science Foundation of China[81773576] |
| WOS研究方向 | Pharmacology & Pharmacy ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000490741500012 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/282690]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Li, Yingxia |
| 作者单位 | 1.Henan Normal Univ, Collaborat Innovat Ctr Henan Prov Green Mfg Fine, Sch Chem & Chem Engn, Key Lab Green Chem Media & React,Minist Educ, Xinxiang 453007, Henan, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Div Antitumor Pharmacol, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China 3.Fudan Univ, Sch Pharm, 826 Zhangheng Rd, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Zhenkang,Ma, Chunhua,Wang, Yujie,et al. Structural optimization and neurotrophic activity evaluation of neurotrophic gentiside derivatives[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2019,29(22):6. |
| APA | Wang, Zhenkang,Ma, Chunhua,Wang, Yujie,Xiao, Qiang,Xu, Chenghui,&Li, Yingxia.(2019).Structural optimization and neurotrophic activity evaluation of neurotrophic gentiside derivatives.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,29(22),6. |
| MLA | Wang, Zhenkang,et al."Structural optimization and neurotrophic activity evaluation of neurotrophic gentiside derivatives".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 29.22(2019):6. |
入库方式： OAI收割
来源：上海药物研究所
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