Enhancement of cisplatin efficacy by lipid-CaO2 nanocarrier-mediated comprehensive modulation of the tumor microenvironment
文献类型：期刊论文
| 作者 | He, Chuanchuan4; Zhang, Xiaojuan4; Yan, Ruicong4; Zhao, Pengxuan4; Chen, Yan4; Li, Minsi4; Chen, Chen4; Fan, Ting4; Lu, Yao4; Wang, Chen1,3 |
| 刊名 | BIOMATERIALS SCIENCE
 |
| 出版日期 | 2019-10-01 |
| 卷号 | 7期号:10页码:4260-4272 |
| ISSN号 | 2047-4830 |
| DOI | 10.1039/c9bm00797k |
| 通讯作者 | Yang, Tan() ; Xiang, Guangya(gyxiang1968@hotmail.com) |
| 英文摘要 | Hypoxia, acidosis and high level of glutathione (GSH) are characteristic abnormalities of the tumor microenvironment (TME), which promote tumor progression, metastasis, and resistance to therapies. Previous attempts to improve therapeutic efficacy were limited to modifying individual TME elements. In this study, we proposed a comprehensive TME modulation strategy that modifies multiple elements of the TME in order to enhance cisplatin anticancer efficacy. To do so, we prepared biocompatible lipid-coated CaO2/cisplatin nanoparticles (LipoCaO(2)/DDP) by the reverse microemulsion method. We imbued CaO2 with the following reverse-TME properties: O-2 generation, increased pH value in tumor cells, and oxidation of intracellular glutathione. In vitro experiments showed that LipoCaO(2)/DDP could deplete GSH for preventing the binding of GSH to cisplatin. Simultaneously, CaO2 could significantly downregulate multidrug resistance-associated protein 2 (MRP2) by O-2-dependent hypoxia-inducible factor 1 (HIF-1) inactivation. Hence, the complete drug-efflux pathway was blocked, and the anticancer effect of cisplatin was enhanced both in vitro and in vivo. Herein, we not only demonstrated the GSH depletion capacity of CaO2 for the first time, but also provided a new comprehensive therapeutic strategy to overcome therapeutic resistance caused by multiple factors in the TME. |
| WOS关键词 | HYPOXIA-INDUCED RESISTANCE ; CALCIUM PEROXIDE ; DRUG-RESISTANCE ; OXYGEN ; NANOPARTICLES ; CANCER ; MECHANISMS ; DELIVERY |
| 资助项目 | Natural Science Foundation of China[81603046] ; Natural Science Foundation of China[81673368] ; Natural Science Foundation of China[81703446] ; Independent Innovation Foundation of Higher Education of China[2016JCTD109] ; Independent Innovation Foundation of Higher Education of China[2016YXMS140] ; Independent Innovation Foundation of Higher Education of China[2016YXMS147] ; National Postdoctoral Program for Innovative Talents[BX201600057] ; China Postdoctoral Science Foundation[2017M612474] ; Fundamental Research Funds for the Central Universities[HUST: 2018JYCXJJ008] |
| WOS研究方向 | Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000487753500024 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/282761]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Yang, Tan; Xiang, Guangya |
| 作者单位 | 1.Chinese Acad Sci, CAS Key Lab Receptor Res, Drug Discovery & Design Ctr, State Key Lab Drug Res,Shanghai Inst Mat Med, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China 2.Des Moines Univ, Coll Med, Des Moines, IA 50312 USA 3.Univ Chinese Acad Sci, 19 Yuquan Rd, Beijing 100049, Peoples R China 4.Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Wuhan 430030, Hubei, Peoples R China 5.Ohio State Univ, Div Pharmaceut & Pharmaceut Chem, Columbus, OH 43210 USA |
| 推荐引用方式 GB/T 7714 | He, Chuanchuan,Zhang, Xiaojuan,Yan, Ruicong,et al. Enhancement of cisplatin efficacy by lipid-CaO2 nanocarrier-mediated comprehensive modulation of the tumor microenvironment[J]. BIOMATERIALS SCIENCE,2019,7(10):4260-4272. |
| APA | He, Chuanchuan.,Zhang, Xiaojuan.,Yan, Ruicong.,Zhao, Pengxuan.,Chen, Yan.,...&Xiang, Guangya.(2019).Enhancement of cisplatin efficacy by lipid-CaO2 nanocarrier-mediated comprehensive modulation of the tumor microenvironment.BIOMATERIALS SCIENCE,7(10),4260-4272. |
| MLA | He, Chuanchuan,et al."Enhancement of cisplatin efficacy by lipid-CaO2 nanocarrier-mediated comprehensive modulation of the tumor microenvironment".BIOMATERIALS SCIENCE 7.10(2019):4260-4272. |
入库方式： OAI收割
来源：上海药物研究所
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