invitrostudiesonthemultitargetantialzheimeractivitiesofberberinelikealkaloidsfromcoptidisrhizoma
文献类型：期刊论文
| 作者 | Hu Ying2; Yang Yanfang2; Yang Wenzhi1; Zhang Yingtao2 |
| 刊名 | journalofchinesepharmaceuticalsciences
 |
| 出版日期 | 2014 |
| 卷号 | 23期号:6页码:385 |
| 关键词 | 黄连 阿尔茨海默病 β淀粉样肽 乙酰胆碱酯酶 β分泌酶 |
| ISSN号 | 1003-1057 |
| 英文摘要 | Coptidis Rhizoma, a well known heat-clearing Chinese Materia Medica, exhibited multi-target anti-Alzheimer effects in vitro through inhibition of Aβ42 aggregation, AChE, and BACE1. Six berberinelike alkaloids were found to be the major active constituents of Coptidis Rhizoma by HPLC analysis along with activity assays. A standard combination of the six major alkaloids was demonstrated to fully reproduce the in vitro effects of Coptidis Rhizoma. Molecular docking studies revealed that berberine-like alkaloids could directly bind at the active sites of Aβ42, AChE, and BACE1 through hydrophobic interactions, aromatic stacking, and electrostatic interactions. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/282877]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.中国科学院上海药物研究所 2.北京大学 |
| 推荐引用方式 GB/T 7714 | Hu Ying,Yang Yanfang,Yang Wenzhi,et al. invitrostudiesonthemultitargetantialzheimeractivitiesofberberinelikealkaloidsfromcoptidisrhizoma[J]. journalofchinesepharmaceuticalsciences,2014,23(6):385. |
| APA | Hu Ying,Yang Yanfang,Yang Wenzhi,&Zhang Yingtao.(2014).invitrostudiesonthemultitargetantialzheimeractivitiesofberberinelikealkaloidsfromcoptidisrhizoma.journalofchinesepharmaceuticalsciences,23(6),385. |
| MLA | Hu Ying,et al."invitrostudiesonthemultitargetantialzheimeractivitiesofberberinelikealkaloidsfromcoptidisrhizoma".journalofchinesepharmaceuticalsciences 23.6(2014):385. |
入库方式： OAI收割
来源：上海药物研究所
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