cucurbitaciniinhibitsstat3butenhancesstat1signalinginhumancancercellsinvitrothroughdisruptingactinfilaments
文献类型：期刊论文
| 作者 | Guo Hui; Kuang Shan; Song Qiaoling; Liu Man; Sun Xiaoxiao; Yu Qiang
|
| 刊名 | actapharmacologicasinica
 |
| 出版日期 | 2018 |
| 卷号 | 039期号:003页码:425 |
| 关键词 | STAT3 信号变换器 房间 细丝 癌症 肌 高通 细胞生长 |
| ISSN号 | 1671-4083 |
| 英文摘要 | STAT1 and STAT3 are two important members of the STAT （signal transducers and activators of transcription） protein family and play opposing roles in regulating cancer cell growth. Suppressing STAT3 and/or enhancing STAT1 signaling are considered to be attractive anticancer strategies. Cucurbitacin I （Cul） isolated from the cucurbitacin family was reported to be an inhibitor of STAT3 signaling and a disruptor of actin cytoskeleton. In this study we investigated the function and mechanisms of Cul in regulating STAT signaling in human cancer cells in vitro. Cul （0.1-10 mmol/L） dose-dependently inhibited the phosphorylation of STAT3, and enhanced the phosphorylation of STAT1 in lung adenocarcinoma A549 cells possibly through disrupting actin filaments. We further demonstrated that actin filaments physically associated with JAK2 and STAT3 in A549 cells and regulated their phosphorylation through two signaling complexes, the 11_-6 receptor complex and the focal adhesion complex. Actin filaments also interacted with STAT1 in A549 cells and regulated its dephosphorylation. Taken together, this study reveals the molecular mechanisms of Cul in the regulation of STAT signaling and in a possible inhibition of human cancer cell growth. More importantly, this study uncovers a novel role of actin and actin-associated signaling complexes in regulating STAT signaling. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/282899]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 中国科学院上海药物研究所 |
| 推荐引用方式 GB/T 7714 | Guo Hui,Kuang Shan,Song Qiaoling,et al. cucurbitaciniinhibitsstat3butenhancesstat1signalinginhumancancercellsinvitrothroughdisruptingactinfilaments[J]. actapharmacologicasinica,2018,039(003):425. |
| APA | Guo Hui,Kuang Shan,Song Qiaoling,Liu Man,Sun Xiaoxiao,&Yu Qiang.(2018).cucurbitaciniinhibitsstat3butenhancesstat1signalinginhumancancercellsinvitrothroughdisruptingactinfilaments.actapharmacologicasinica,039(003),425. |
| MLA | Guo Hui,et al."cucurbitaciniinhibitsstat3butenhancesstat1signalinginhumancancercellsinvitrothroughdisruptingactinfilaments".actapharmacologicasinica 039.003(2018):425. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。